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Drug-induced enterocolitis syndrome: Similarities and differences compared with food protein-induced enterocolitis syndrome |
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| Authors: | Francesca Mori Giulia Liccioli Oliver Fuchs Simona Barni Mattia Giovannini Lucrezia Sarti Elio Novembre Jean-Christoph Caubet |
| Affiliation: | 1. Department of Paediatric Medicine, Allergy Unit, Meyer Children's Hospital, Florence, Italy;2. Division of Pediatric Allergology and Pulmonology, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland;3. Department of Paediatric Medicine, Allergy Unit, Meyer Children's Hospital, Florence, Italy Contribution: Validation (equal);4. Department of Paediatric Medicine, Allergy Unit, Meyer Children's Hospital, Florence, Italy Contribution: Conceptualization (equal);5. Department of the Child and Adolescent, Pediatric Allergy Units, Geneva University Hospitals, Geneva, Switzerland |
| Abstract: | In 2014, drug-induced enterocolitis syndrome (DIES) was described for the first time. It is still a poorly known disease with symptoms that typically resemble those of food protein–induced enterocolitis syndrome (FPIES). To date, six more cases of DIES have been described and new clinical diagnostic criteria have been proposed based on those in the international guidelines for FPIES. In this paper, the authors describe three more cases of DIES. In addition, similarities and differences with FPIES have been deeply analyzed. To date, several unanswered questions need to be addressed, but clinicians must be instructed how to identify DIES, in order to make an allergy workup and give definite therapeutic indications to patients, especially in children where DIES seems to be more frequent. |
| Keywords: | beta-lactams children drug hypersensitivity reactions drug-induced enterocolitis syndrome food protein–induced enterocolitis syndrome |