Pruritus in neuromyelitis optica spectrum disorders and multiple sclerosis |
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| Affiliation: | 1. Chinese PLA Medical College, 28# Fuxing Road, Beijing, People’s Republic of China;2. Neurology Department, First Medical Center, Chinese PLA General Hospital, 28# Fuxing Road, Beijing, People’s Republic of China;3. School of Dental Medicine, Stony Brook University, South Dr, Stony Brook, NY 11794, United States;1. Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea;2. Department of Radiology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea;3. Department of Neurosurgery, Eunpyeong St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;4. Department of Neurology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;1. Department of Orthopaedics, Nagoya University Graduate School of Medicine, Aichi, Japan;2. Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan;1. Department of Neurosurgery, Auckland City Hospital, Auckland, New Zealand;2. Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand;3. The Centre for Brain Research, University of Auckland, Auckland, New Zealand;4. Department of Pharmacology, University of Auckland, Auckland, New Zealand;5. Department of Diagnostic Radiology, Middlemore Hospital, Auckland, New Zealand;6. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;1. Department of Neurology, Beichen Traditional Chinese Medical Hospital, Tianjin, China;2. Department of Internal Medicine, Characteristic Medical Center of Chinese People’s Armed Police, Tianjin,China |
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| Abstract: | PurposeDifferential diagnosis between neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) at early stage remains challenging at present. Pruritus is reported as a common or specific feature in NMOSD with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). We aim to verify whether pruritus can help in distinguishing NMOSD from MS.MethodsWe retrospectively reviewed the medical records of consecutive cases of NMOSD and MS patients, demographic data, clinical features, whether or not had pruritus, serum AQP4-IgG status and magnetic resonance imaging (MRI) results.Results21.0% (22/105) of NMOSD patients and 2.1% (2/96) of MS patients reported pruritus during disease course (p < 0.01). 20.5% (18/88) of AQP4-IgG positive and 23.5% (4/17) of AQP4-IgG negative NMOSD patients reported pruritus during disease course (p = 0.775). 12.4% (13/105) of NMOSD and 1.0% (1/96) of MS patients reported pruritus at the first attack episode of disease (p < 0.01). 20.0% (21/105) of NMOSD and 1.0% (1/96) of MS patients reported pruritus at the first and second attack episodes of disease (p < 0.01).ConclusionPruritus is a common and relatively specific feature in either AQP4-IgG positive or negative NMOSD. Pruritus occurs more frequently in NMOSD than MS, which may help in distinguishing NMOSD from MS, especially at early stage. |
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| Keywords: | Pruritus Neuromyelitis optica spectrum disorders Multiple sclerosis Aquaporin-4 immunoglobulin G antibody |
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