| 中药雄黄的致突变性实验研究 |
| |
| 引用本文： | 孙恩亭,卜新柱.中药雄黄的致突变性实验研究[J].中国中医基础医学杂志,1998,4(11):52-52. |
| |
| 作者姓名： | 孙恩亭 卜新柱 |
| |
| 作者单位： | 中国中医研究院基础理论研究所，北京医科大学，北京安贞医院 |
| |
| 基金项目： | 国家中医药管理局科研基金 |
| |
| 摘 要： | 目的研究中药雄黄对小鼠的致突变作用。方法用雄性小鼠灌胃服用不同剂量的雄黄共６周，同时设立阴性对照（蒸馏水）和阳性对照（环磷酰胺），测定其骨髓嗜多染红细胞微核发生率的变化。结果以剂量１．０ｇ／ｋｇ诱发雄性小鼠的微核率显著高于阴性对照，Ｐ＜０．０１，而且随着雄黄剂量增加，骨髓嗜多染红细胞的微核率升高。结论雄黄具有潜在致突变性
|
| 关 键 词： | 雄黄 微核试验 致突变性 |
Study on mutagenicity of xiong huang |
| |
| Sun Enting et al.Study on mutagenicity of xiong huang[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,1998,4(11):52-52. |
| |
| Authors: | Sun Enting |
| |
| Abstract: | This paper reported the research results of mutagenicity of chinens medicine xiong huang.The mutagenicity of xiong huang was studied by PCE mouse marrow micronucleus assay.Mice were administered xiong huang via oral at doses of 0.4/kg,1.0g/kg and 2.0g/kg respectively for 42 days.The results showed that xiong huang more than 1.0g/kg dose could induce male mice marrow micronucleus rates increase ( P <0 01),dous effect was found.So xiong huang is mutagenic. |
| |
| Keywords: | Xiong huang Micronucleus Mutagenicity |
| 本文献已被 CNKI 维普 等数据库收录！ |
