| 4-(1-苯并三氮唑甲基)苯丙烯酸钠的合成 |
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| 引用本文： | 罗惠善,金雪梅,林胜杰. 4-(1-苯并三氮唑甲基)苯丙烯酸钠的合成[J]. 延边医学院学报, 2003, 26(4): 266-268 |
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| 作者姓名： | 罗惠善 金雪梅 林胜杰 |
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| 作者单位： | [1]延边大学药学院物理化学教研室，吉林延吉133000 [2]延边大学医学院附属医院药剂科，吉林延吉133000 |
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| 摘 要： | [目的] 合成类心血管药物血栓烷合成酶抑制剂并观察其抗实验性心律失常作用。[方法] 将甲苯作为起始原料，采用亲电取代、claisen-schmidt反应、溴化及相转移催化等方法。[结果] 合成了类心血管药物血栓烷合成酶抑制剂即4-(1-苯并三氮唑甲基)苯丙烯酸钠。
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| 关 键 词： | 心律失常 抗心律失常药 大鼠 合成 4-（1-苯并三氮唑甲基）苯丙烯酸钠 |
| 文章编号： | 1000-1824(2003)04-0266-03 |
| 修稿时间： | 2003-06-29 |
Synthesis of the 4-(1-benzotriazol-1-ylmethyl-phenyl)-acrylic acid sodium and its antiarrhythmic activities |
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| LUO Hui-shan ,JIN Xue-mei ,LIN Sheng-jie. Synthesis of the 4-(1-benzotriazol-1-ylmethyl-phenyl)-acrylic acid sodium and its antiarrhythmic activities[J]. Journal of Medical Science Yanbian University, 2003, 26(4): 266-268 |
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| Authors: | LUO Hui-shan JIN Xue-mei LIN Sheng-jie |
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| Affiliation: | LUO Hui-shan 1,JIN Xue-mei 2,LIN Sheng-jie 1 |
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| Abstract: | OBJECTIVETo synthesize a new inhibitor f or thromboxane A 2 synthase and observe its antiarrhythmic effect.M ETHODS The toluene was as the original raw material, and the experiment was performed by the methods of electrphilic substitution, claisen-schmidt reac tion, bromide and mutual transferring catalyze.RESULTSThe inhibit or for thromboxane A 2 synthase, 4-(1-Benzotriazol-1-ylmethyl- phenyl)-ac rylic acid sodium was successfully synthesized. |
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| Keywords: | arrhythmia anti-arrhythmia agents rats |
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