T1-3N0分化型甲状腺癌的外科治疗及其疗效分析

背景与目的:分化型甲状腺癌原发灶的手术方式一直存在争议,主要是对局限于一侧腺叶的病变选择甲状腺全切除还是采用单叶切除。本研究的目的是探讨T1-3N0分化型甲状腺癌外科治疗的方式及其远期疗效。方法:回顾性分析1985年至2000年在我院首治、术后病理分期为T1-3N0的分化型甲状腺癌患者153例,探讨其原发灶的多中心性、手术治疗方式及预后情况。结果:153例分化型甲状腺癌患者中21例有多中心癌灶,其中12例为单叶多中心癌灶,9例为双侧腺叶多中心癌灶。92例患者行癌侧腺叶 峡部切除术,44例行癌侧腺叶次全 峡部切除术;9例有双侧叶多发癌灶的患者中7例行一侧腺叶 峡部 对侧腺叶次全切除术,2例行双侧腺叶次全切除术;8例原发灶位于峡部的患者行峡部 双侧叶部分切除术。手术后出现区域淋巴结转移7例,其中6例为颈部淋巴结转移,1例为上纵隔淋巴结转移;出现远处转移5例。本组患者的5、10和15年生存率分别为98.7%、96.1%和86.9%。单因素分析显示影响患者生存的因素包括年龄、病理类型、肿瘤大小和远处转移(P<0.05);年龄<45岁、肿瘤大小≤4cm、病理为乳头状癌或混合型癌和无远处转移者预后较好。Cox分析显示年龄和远处转移是影响患者生存的独立因素。结论:对T1-3N0分化型甲状腺癌患者的手术治疗可采用癌侧腺叶 峡部切除或癌侧腺叶次全 峡部切除术。T1-3N0分化型甲状腺癌患者的远期疗效较好,影响其生存的因素包括年龄、病理类型、肿瘤大小和远处转移。

Surgical treatment and long-term efficacy on stage T1-3N0 differentiated thyroid carcinoma

BACKGROUND & OBJECTIVE: Whether to choose total thyroidectomy or lobectomy for the primary lesion of differentiated thyroid carcinoma (DTC) limited in one lobe is controversial. This study was to investigate the patterns of surgical treatment for stage T1-3N0 DTC, and observe the long-term efficacy. METHODS: Clinical data of 153 DTC patients, first treated at Cancer Center of Sun Yat-sen University from 1985 to 2000, were reviewed. The postoperative pathologic stage of these patients was T1-3N0. The multiple centricity of primary lesions, patterns of surgical treatment, and prognosis were analyzed. RESULTS: Of the 153 DTC patients, 21 had cancer multifocality: 12 had multiple cancer foci in one lobe and 9 had cancer multifocality in both lobes. Ninety-two patients received unilateral lobectomy plus isthmectomy; 44 patients received ipsilateral subtotal lobectomy plus isthmectomy. Among the 9 patients who had cancer multifocality in both lobes, 7 received unilateral lobectomy plus isthmectomy with contralateral subtotal lobectmoy and 2 received bilateral subtotal lobectomy. Eight patients, whose primary lesions were at isthmus, underwent isthmectomy plus bilateral partial lobectomy. Regional lymph node metastasis appeared in 7 patients after initial operation: 6 in the neck and 1 in the upper mediastinum. Five patients had distant metastasis after operation. The 5-, 10-and 15-year survival rates of these 153 patients were 98.7%, 96.1% and 86.9%, respectively. Age, pathologic type, tumor size and distant metastasis affected the survival (P<0.05). The patients whose age was less than 45 years, tumor size was less than 4 cm, pathologic type was papillary or mixed carcinoma, and who had no distant metastasis had relatively good prognosis. Age and distant metastasis were independent prognostic factors. CONCLUSIONS: It is feasible to perform unilateral lobectomy or subtotal lobectomy plus isthmectomy for patients with stage T1-3N0 DTC. The long-term outcomes of stage T1-3N0 DTC patients are relatively well. Age, pathologic type, tumor size and distant metastasis affect prognosis.