SIE,SIES, GITMO revised guidelines for the management of follicular lymphoma |
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| Authors: | Pier Luigi Zinzani Monia Marchetti Atto Billio Giovanni Barosi Angelo Michele Carella Mario Lazzarino Maurizio Martelli Alessandro Rambaldi Luigi Rigacci Corrado Tarella Umberto Vitolo Sante Tura |
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| Affiliation: | 1. Istituto di Ematologia ed Oncologia Medica “Seragnoli,”, Università di Bologna, , Bologna, Italy;2. Unità di Ematologia, Ospedale Cardinal Massaia, , Asti, Italy;3. Unità di Ematologia, Ospedale Civile di Bolzano, , Bolzano, Italy;4. Laboratory of Clinical Epidemiology and Center of the Study of Myelofibrosis, Fondazione IRCCS Policlinico San Matteo, , Pavia, Italy;5. Divisione di Ematologia I, IRCCS Azienda Ospedaliera Universitaria San Martino, , Genova, Italy;6. Divisione di Ematologia, Fondazione IRCCS Policlinico San Matteo, , Pavia, Italy;7. Dipartimento di Biotecnologie Cellulari ed Ematologia, Cattedra di Ematologia, Università La Sapienza, , Roma;8. Divisione di Ematologia, Spedali Riuniti, , Bergamo, Italy;9. Unit of Hematology, AOU Careggi, University of Florence, , Firenze, Italy;10. Divisione di Ematologia, Ospedale Mauriziano, , Torino, Italy;11. Divisione di Ematologia, Azienda Ospedaliera San Giovanni Battista, , Torino, Italy;12. Department of Hematology, University of Bologna, , Bologna, Italy |
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| Abstract: | ![]()
By using the GRADE system, we updated the guidelines for management of follicular cell lymphoma issued in 2006 from SIE, SIES, and GITMO group. We confirmed our recommendation to frontline chemoimmunotherapy in patients with Stage III–IV disease and/or high tumor burden. Maintenance rituximab was also recommended in responding patients. In patients relapsing after an interval longer than 12 months from frontline therapy, we recommended chemoimmunotherapy with non cross‐resistant regimens followed by rituximab maintenance. High dose chemotherapy followed by hematopoietic stem cell transplant was recommended for young fit patients who achieve a response after salvage chemoimmunotherapy. Am. J. Hematol. 88:185–192, 2013. © 2012 Wiley Periodicals, Inc. |
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