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| 虎杖中二氢乳清酸脱氢酶抑制剂的虚拟筛选 | |
| 引用本文： | 张明波,张蕾,黄婷,栾泽柱,郭晏华. 虎杖中二氢乳清酸脱氢酶抑制剂的虚拟筛选[J]. 辽宁中医杂志, 2013, 0(11): 2326-2327 |
| 作者姓名： | 张明波 张蕾 黄婷 栾泽柱 郭晏华 |
| 作者单位： | 辽宁中医药大学药学院,辽宁大连116600 |
| 摘 要： | 目的:从中药虎杖中筛选二氢乳清酸脱氢酶的抑制剂。方法:利用Autodock Tool软件,将二氢乳清酸脱氢酶与虎杖中48个化合物进行对接。结果:虎杖中的大黄素-1-O-β-D-吡喃葡萄糖苷、槲皮素-3-O-阿拉伯糖苷、2,3,5,4'-四羟基芪-2-O-β-D-葡萄糖苷等6个成分对二氢乳清酸脱氢酶具有较强的抑制作用。结论:虎杖可能通过抑制二氢乳清酸脱氢酶发挥抗肿瘤和抗免疫作用。 |
| 关 键 词： | 虎杖 二氢乳清酸脱氢酶 虚拟筛选 抗肿瘤 |
Virtual Screening for Inhibitor of Dihydroorotate Dehydrogenase in Polygonum Cuspidatum Sieb. et Zucc |
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| ZHANG Mingbo,ZHANG Lei,HUANG Ting,LUAN Zezhu,GUO Yanhua. Virtual Screening for Inhibitor of Dihydroorotate Dehydrogenase in Polygonum Cuspidatum Sieb. et Zucc[J]. Liaoning Journal of Traditional Chinese Medicine, 2013, 0(11): 2326-2327 | |
| Authors: | ZHANG Mingbo ZHANG Lei HUANG Ting LUAN Zezhu GUO Yanhua |
| Affiliation: | ( Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning, China) |
| Abstract: | Objective ： To find out inhibitors of dihydroorotate dehydrogenase contained in in Polyonum Cuspidatum Sieb. et Zucc. Methods：Using Autodock Vina sofeware ,48 ingredients in Polyonum Cuspidatum Sieb. et Zucc were docked with dihydroorotare dehydrogenase. Results ：6 chemicals including Emodin-1 -O-β-D-glucopyranoside, Quercetin-3-O-arabinoside , 2,3,5,4＇-Tet- rahydroxystilbene-2-O-β-D-gucoside and others were showed to inhibit dihydroorotate dehydrogenase effectively. Conclusion：Poly- gonumcuspidatum Sieb. et Zucc may exert action in treatment for cancer and autoimmune disease by inhibiting dihydroorotate dehydrogenase. |
| Keywords: | Polygonum cuspidatum Sieb. et Zucc. Dihydroorotate Dehydrogenase virtual screening antitumor |
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