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| 电针对血管性痴呆大鼠血清、脑组织中乙酰胆碱酯酶活性及学习记忆能力的影响 | |
| 引用本文： | 高康,李飞,张庆萍,翟亮. 电针对血管性痴呆大鼠血清、脑组织中乙酰胆碱酯酶活性及学习记忆能力的影响[J]. 辽宁中医杂志, 2013, 0(11): 2367-2368 |
| 作者姓名： | 高康 李飞 张庆萍 翟亮 |
| 作者单位： | [1]武汉市中医医院,湖北武汉430010 [2]安徽中医药大学附属针灸医院,安徽合肥230061 [3]安徽中医药大学,安徽合肥230038 |
| 基金项目： | 国家自然科学基金资助项目（81001558） |
| 摘 要： | 目的:观察电针中冲、涌泉穴对VD大鼠血清、脑组织中乙酰胆碱酯酶(AchE)活性及学习记忆能力的影响。方法:四血管阻断法制作VD大鼠模型,将VD大鼠随机分为模型组、电针组和西药组。采用跳台试验检测学习记忆能力;采用ELISA法测定AchE活性。结果:电针组大鼠跳台反应期时间比模型组缩短(P<0.05);电针组大鼠脑组织和血清中AchE活性显著低于模型组(P<0.01)。结论:电针能改善VD大鼠血清和脑组织中AchE活性,从而提高VD大鼠学习记忆能力。 |
| 关 键 词： | 电针 血管性痴呆 乙酰胆碱酯酶 |
Effects of Electroacupuncture on Serum and Cerebral AchE Activity and Learning-memory Ability in Vascular Dementia Rats |
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| GAO Kang,LI Fei,ZHANG Qingping,ZHAI Liang. Effects of Electroacupuncture on Serum and Cerebral AchE Activity and Learning-memory Ability in Vascular Dementia Rats[J]. Liaoning Journal of Traditional Chinese Medicine, 2013, 0(11): 2367-2368 | |
| Authors: | GAO Kang LI Fei ZHANG Qingping ZHAI Liang |
| Affiliation: | 1. Wuhan Hospital of TCM, Wuhan 430010, Hubei, China ;2. Affiliated Acupuncture Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230061, Auhui, China ;3. Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui, China) |
| Abstract: | Objective：To observe the effect of electroacupuncture （EA） at Zhongchong and Yongquan on metabolism of learning - memory ability and Ache activity in serum and cerebral of VD rats. Methods ： VD model was established by using modified 4 - vessels occlusion method. The VD rats were randomly divided into model, EA and medication groups. The changes of learning- memory ability were investigated by step-down test. AchE activity was measured by ELISA. Results ： The EA group reaction period of step-down test was decreased compared with those in the model group （ P 〈 0. 05 ）. Serum and cerebral AchE activity in EA group was considerably lower than those in model group （ P 〈 0. 01 ）. Conclusion ： EA can reduce serum and cerebral AchE activity, and improve the learning- memory ability in VD rats. |
| Keywords: | electroacupuncture vascular dementia AchE |
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