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| 姜黄素衍生物对糖尿病小鼠糖耐量及脂代谢的影响 | |
| 引用本文： | 刘洋,郑斌,许秀枝,许建华. 姜黄素衍生物对糖尿病小鼠糖耐量及脂代谢的影响[J]. 福建医科大学学报, 2010, 44(3): 168-171 |
| 作者姓名： | 刘洋 郑斌 许秀枝 许建华 |
| 作者单位： | 1. 福建医科大学,药学院药物化学系,福州,350004 2. 福建医科大学,附属协和医院药剂科,福州,350001;福建医科大学,药学院药理学系,福州,350004 3. 福建医科大学,药学院药理学系,福州,350004;福建医科大学,新药研究所,福州,350004 |
| 基金项目： | 福建省科技厅资助省属高校项目,福建省青年人才创新项目 |
| 摘 要： | 目的观察姜黄素（Cur）衍生物对糖尿病模型小鼠糖耐量及脂代谢的影响。方法以芳香醛、乙酰丙酮为原料,通过Claisen-Schmidt缩合制备Cur衍生物L3,以Cur为原料氢化还原得到四氢姜黄素。化合物L3,四氢姜黄素,Cur和普罗布考对链脲佐菌素诱导糖尿病模型小鼠灌胃给药,葡萄糖氧化酶法测血糖,酶比色法测总胆固醇和甘油三酯。SPSS13.0软件处理数据并做生存分析曲线。结果化合物L3灌胃1 g.kg-1.d-1可提高生存率,改善糖尿病高血脂的糖耐量,降低血清总胆固醇。结论化合物L3具有改善糖尿病模型小鼠脂代谢的新功能。 |
| 关 键 词： | 姜黄素 普罗布考 糖尿病 疾病模型 动物 |
Effect of Curcumin Derivatives on Glucose Tolerance and Lipid Metabolism in Diabetic Mice |
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| LIU Yang,ZHENG bin,XU Xiuzhi,XU Jianhua. Effect of Curcumin Derivatives on Glucose Tolerance and Lipid Metabolism in Diabetic Mice[J]. Journal of Fujian Medical University, 2010, 44(3): 168-171 | |
| Authors: | LIU Yang ZHENG bin XU Xiuzhi XU Jianhua |
| Affiliation: | LIU Yang1,ZHENG bin2,3,XU Xiuzhi1,XU Jianhua3,41.Department of medicinal chemistry,School of Pharmacy,Fujian Medical University,Fuzhou 350004,China,2.Department of Pharmacy,The Affiliated Union Hospital,Fuzhou 350001,3.Department of Pharmacology,China4.Institute of New Drug Research |
| Abstract: | Objective To investigate the effect of curcumin derivatives on glucose tolerance and lipid metabolism in diabetic mice.Methods L3 was synthesized with aromatic aldehyde and acetylacetone by Claisen-Schmidt condensation.Tetrahydrocurcumin was synthesized with curcumin by hydrogenation.Compound L3,tetrahydrocurcumin,curcumin and probucol were administered to streptozotocin-induced diabetic mice.Glucose was measured by Glucose oxidase method.Total cholesterol and triglycerides were examined by enzyme colorimet... |
| Keywords: | CURCUMIN Probucol diabetes mellitus disease models animal |
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