人类免疫缺陷病毒感染与心力衰竭发生风险—基于前瞻性队列研究的Meta分析

 目的 探讨人类免疫缺陷病毒（HIV）感染与心力衰竭发生风险的关系。方法 检索PubMed、Embase、中国生物医学文献数据库、中国知网、万方数据库、维普中文科技期刊数据库,收集已发表的HIV感染与心力衰竭发生风险的前瞻性队列研究,应用Stata 12.0软件进行Meta分析,合并风险比（HR）值及95%置信区间（CI）值。结果 最终纳入5项研究,HIV感染暴露组84 557例,非HIV感染暴露组219 177例。Meta分析结果显示,HIV感染可使心力衰竭发生风险增加48%（HR=1.48,95%CI：1.31~1.67,P<0.001）;按照HIV-1 RNA病毒载量、CD4⁺细胞计数、研究人群来源进行亚组分析,结果显示研究异质性主要来自于研究人群中退役军人组。结论 HIV感染可能是心力衰竭发生的危险因素之一,可增加心力衰竭发生的风险。

HIV infection and onset risk of heart failure: a Meta-analysis based on prospective cohort studies

Objective To explore the relationship between human immunodeficiency virus (HIV) infection and onset risk of heart failure(HF). Methods PubMed, Embase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure(CNKI), Wanfang Database, and VIP Database were searched,the published prospective cohort studies on HIV infection and onset risk of HF were collected, Meta-analysis was conducted with Stata 12.0 software, pooled hazard ratio (HR) and corresponding 95% confidence interval(CI) was calculated. Results Five studies were included, 84 557 were in HIV infection exposed group and 219 177 in non-HIV infection exposed group. Meta-analysis showed that HIV infection may increase the onset risk of HF by 48%(HR=1.48,95%CI:1.31-1.67,P<0.001); subgroup analysis was conducted according to HIV-1 RNA viral load, CD4⁺ cell count and source of population in the study, results showed that the heterogeneity of this study may be due to veterans group in the study population. Conclusion HIV infection may be one of risks of onset of HF, which may increase onset risk of HF.