| 下丘脑-垂体-肾上腺轴和褪黑素对行为发育的调节作用 |
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| 引用本文： | 王艳霞. 下丘脑-垂体-肾上腺轴和褪黑素对行为发育的调节作用[J]. 医学综述, 2010, 16(22) |
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| 作者姓名： | 王艳霞 |
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| 基金项目： | 福建医科大学重点科研项目基金，福建医科大学协和临床学院教授基 |
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| 摘 要： | 儿童行为发育受遗传因素与外界环境因素共同影响。生命早期环境可通过大脑和神经内分泌功能影响个体行为发育。下丘脑-垂体-肾上腺(HPA)轴被认为是环境因素影响个体行为发育的一个重要环节。褪黑素是松果腺分泌的一种神经内分泌激素,参与应激反应,并可通过抑制HPA轴的过度激活来调节HPA轴功能,从而对脑的发育发挥保护作用。
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| 关 键 词： | 行为发育 下丘脑-垂体-肾上腺轴 褪黑素 糖皮质激素受体 |
Effects of Hypothalamic-Pituitary-Adrenal Axis and Melatonin on Behavioral Development in Children |
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| WANG Yan-xia. Effects of Hypothalamic-Pituitary-Adrenal Axis and Melatonin on Behavioral Development in Children[J]. Medical Recapitulate, 2010, 16(22) |
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| Authors: | WANG Yan-xia |
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| Abstract: | Behavioral development of children are affected by both genetic factors and environmental factors.Exposure to stress early in life has effects on the hypothalamic-pituitary-adrenal(HPA)axis and the brain.HPA axis performances an important part in environmental factors affecting individual behavior development.Melatonin is a neuroendocrine hormone secreted by pineal gland involved in stress response,and may inhibit the HPA axis hyperactivity acting as a protective factor on the brain development. |
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| Keywords: | Behavioral development HPA axis Melatonin Glucocorticoid receptor |
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