The roles of CD8 in cytotoxic T lymphocyte function |
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| Affiliation: | 1. Department of Prevention Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, China;2. Gastrointestinal Surgery Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China;3. Yinzhou Branch of Ningbo Public Security Bureau, Ningbo, Zhejiang 315100, China;4. Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China |
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| Abstract: | ![]()
The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding. |
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