Restorative effect of short term administration of thymulin on thymus-dependent antibody production in restraint-stressed mice |
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| Affiliation: | 1. Department of Cardiology, Keio University School of Medicine, Tokyo, Japan;2. Department of Cardiovascular Surgery, Keio University School of Medicine, Tokyo, Japan;3. Department of Organ Fabrication, Keio University School of Medicine, Tokyo, Japan;4. Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan;5. Suzuki Precision Co., Ltd., Tochigi, Japan;6. Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan;1. College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang 324000, PR China;2. Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, PR China;3. Zhejiang Yilong Environmental Protection Technology Co., Taiyue Digital Port, Xiaoshan District, Hangzhou 311202, PR China;4. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China;5. Zhongyuan Energy Company Limited, Beijing 100084, PR China |
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| Abstract: | ![]()
Thymulin is a well defined nonapeptide produced by thymic epithelial cells, and plays an important role in thymocyte differentiation. We investigated the restorative effect of thymulin on the stress-induced reduction in the production of antibodies against SRBC in mice. Antibody production in stressed mice was reduced to about 50% of that in normal mice. A 3-day period of administration of thymulin (1 ng/kg) restored antibody production to close to the normal level, whereas thymulin (1 ng−1 μg/kg) did not affect antibody production in normal mice. These results indicated that thymulin normalizes the altered thymus-dependent immune responses. |
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