Potential antitumor agents. XX (1) 6-anilinoimidazo[2,1-b]thiazoles |
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| Affiliation: | 1. Dipartimento di Scienze Farmaceutiche, Universitá di Bologna, Via Belmeloro 6, 40126 Bologna, Italy;2. Dipartimento di Farmacologia, C.T.M., Università di Milano, Via Vanvitelli 32, 20129 Milano, Italy;1. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Via Archirafi 32, 90123 Palermo, Italy;2. Department of Organic Chemistry, Semmelweis University, Högyes E. u. 7, H-1092 Budapest, Hungary;1. School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia;2. School of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia;3. Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20057, USA;4. Bionomics Limited, Thebarton, SA 5031, Australia;5. CSIRO Materials Science & Engineering, Ian Wark Laboratory, Bayview Avenue, Clayton Victoria 3168, Australia;6. Discipline of Medical Radiation Sciences, The University of Sydney, Sydney, NSW 2006, Australia;7. Brain and Mind Research Institute, Sydney, NSW 2050, Australia;1. Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary;2. Stereochemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary;1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8558, USA;2. Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale School of Medicine, Yale University, 300 Cedar Street TAC441S, New Haven, CT 06520-8057, USA;1. Department of Studies in Physics, University of Mysore, Manasagangotri, Mysuru 570006, Karnataka, India;2. Department of Chemistry, SJCE, JSS Science and Technology University, Mysuru 570006, Karnataka, India;3. Department of Biotechnology, University of Mysore, Manasagangotri, Mysuru 570006, Karnataka, India;4. Department of Chemistry, An-Najah National University, P.O. Box 7, Nablus, Palestine, Israel |
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| Abstract: | ![]()
The synthesis of 6-anilinoimidazo[2,1-b]thiazoles, related to the well-known antitumor agent amsacrine, is reported. The cytotoxic activity of the new compounds was evaluated on HeLa cells. Compound 3a, the most closely related to amsacrine, was significantly active. |
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