| CYP2D6＊10等位基因多态性对胃癌术后曲马多镇痛效果的影响 |
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| 引用本文： | 汪国香,黄丽霞,张相彩,陶凡.CYP2D6＊10等位基因多态性对胃癌术后曲马多镇痛效果的影响[J].中国中西医结合外科杂志,2011,17(5):465-468. |
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| 作者姓名： | 汪国香 黄丽霞 张相彩 陶凡 |
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| 作者单位： | 1. 浙江省中西医结合医院麻醉疼痛科,杭州,310003
2. 浙江省中西医结合医院临床药理科,杭州,310003 |
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| 基金项目： | 杭州市医药卫生科技计划项目，浙江省公益性技术应用研究计划项目 |
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| 摘 要： | 目的：探讨中国人群CYP2D6＊10等位基因对胃癌术后曲马多镇痛效果的影响。方法：70例胃癌根治术患者,手术结束前30min静脉注入负荷剂量曲马多100mg,随后采用持续背景剂量-PCA量的给药模式（曲马多10mg/mL、甲氧氯普胺0.3mg/mL）进行术后镇痛。全麻诱导后抽取血样,采用聚合酶链反应-限制性片断长度多态性方法分析患者CYP2D6＊10基因多态性,根据不同CYP2D6基因型分为3组,比较不同基因组患者之间曲马多的用量。结果：CYP2D6＊10等位基因频率为52.4%,不携带CYP2D6＊10（I组）17例,CYP2D6＊10杂合子（II组）26例,CYP2D6＊10纯合子（III组）20例。48h曲马多用量,III组明显高于I组和II组,I组和II组之间差异无统计学意义。结论：在中国人群中,CYP2D6＊10等位基因对曲马多镇痛效果有显著影响。
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| 关 键 词： | 细胞色素P4502D6 等位基因 曲马多 术后疼痛 中国人群 |
Effect of the CYP2D6*10 allele on postoperative tramadol analgesia in patients after gastric cancer surgery |
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| Wang Guoxiang,Huang Lixia,Zhang Xiangcai,et al..Effect of the CYP2D6*10 allele on postoperative tramadol analgesia in patients after gastric cancer surgery[J].Chinese Journal of Surgery of Integrated Traditional and Western Medicine,2011,17(5):465-468. |
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| Authors: | Wang Guoxiang Huang Lixia Zhang Xiangcai |
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| Institution: | Wang Guoxiang,Huang Lixia,Zhang Xiangcai,et al.Integrated Chinese and Western Medicine Hospital of Zhejiang Province,Hangzhou (310003),China |
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| Abstract: | Objective To investigate whether the CYP2D6*10 allele has an impact on the postoperative analgesia effect of tramadol in Chinese patients suffering from gastric cancer surgery.Methods Seventy gastric cancer patients suffering from gastrectomy were enrolled.After receiving a loading dose of 100 mg tramadol intravenously,patients could self-administer doses of 10 mg/mL tramadol plus 0.3 mg/mL metoclopramide via patient-controlled analgesia (PCA).Blood samples were collected after induction of anesthesia.The C... |
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| Keywords: | Cytochrome P4502D6 Allele frequency Tramadol Postoperative pain Chinese population |
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