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| 海洛因依赖者的海马容积和磁共振质子波谱研究 | |
| 引用本文： | 夏军,罗学东,程建平,陈友之,何纯正,周义成. 海洛因依赖者的海马容积和磁共振质子波谱研究[J]. 中国药物依赖性杂志, 2005, 14(1): 38-41,53 |
| 作者姓名： | 夏军 罗学东 程建平 陈友之 何纯正 周义成 |
| 作者单位： | 1. 深圳市第二人民医院放射科,深圳,518035 2. 武汉市精神卫生中心,武汉,430022 3. 华中科技大学同济医学院附属同济医院放射科,武汉,430030 |
| 摘 要： | 目的 :探讨海洛因依赖者海马容积与磁共振质子波谱 (1 HMRS)的改变特征。方法 :对 13例海洛因依赖者和12例健康对照组行磁共振 (MRI)海马容积测量和1 HMRS检查。结果 :海洛因依赖者显示双侧海马容积比正常对照组有明显缩小 ,差异有显著性 (P <0 0 5 ) ;双侧海马1 HMRS示NAA Cr低于正常对照组 ,差异有显著性 (P <0 0 5 )。结论 :海马参与了海洛因依赖的病理生理过程 ,1 HMRS能显示海马区的神经元受损。 |
| 关 键 词： | 海洛因依赖 海马 磁共振成像 磁共振波谱 |
STUDY ON THE VOLUME AND 1HMRS OF HIPPOCAMPUS OF HEROIN DEPENDENCT PATIENTS |
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| XIA Jun,LUO Xuedong,CHENG Jianping,CHEN Youzhi,HE Chunzhe ng,ZHOU Yicheng. STUDY ON THE VOLUME AND 1HMRS OF HIPPOCAMPUS OF HEROIN DEPENDENCT PATIENTS[J]. Chinese Journal of Drug Dependence, 2005, 14(1): 38-41,53 | |
| Authors: | XIA Jun LUO Xuedong CHENG Jianping CHEN Youzhi HE Chunzhe ng ZHOU Yicheng |
| Affiliation: | XIA Jun1,LUO Xuedong2,CHENG Jianping2,CHEN Youzhi2,HE Chunzhe ng2,ZHOU Yicheng3 1 |
| Abstract: | Objective: To study the MRI volum e of hippocampus and changes of 1HMRS in patients with heroin dependence. Methods: MRI and 1HMRS were performed in 13 heroin abuser s and 12 non-drug abusers as control. Results: The volume of bilateral hippocampus of the patients was significantly smaller compared with th e controls'. 1HMRS revealed that NAA/Cr ratio in the patients was reduced. Conclusion: The results of this study supports to the view that hippocampus may participate in the pathophysiology of heroin depe ndence. The reduced NAA/Cr on 1HMRS provides evidence for neuronal damage in heroin abusers. |
| Keywords: | heroin dependence hippocampus magnetic resonance imaging magnetic resonance spectroscopy |
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