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| 链脲佐菌素诱导大鼠2型糖尿病免疫模型的建立 | |
| 引用本文： | 谢宁,井宏颖,吴颂,郑楠,张良. 链脲佐菌素诱导大鼠2型糖尿病免疫模型的建立[J]. 辽宁中医药大学学报, 2011, 0(4): 5-6 |
| 作者姓名： | 谢宁 井宏颖 吴颂 郑楠 张良 |
| 作者单位： | 黑龙江中医药大学中医基础理论教研室; |
| 基金项目： | 教育部春晖计划资助项目(5030411) |
| 摘 要： | 目的:建立一种类似人2型糖尿病的免疫动物模型。方法:雄性Wistar成年大鼠高糖高脂饲料喂养,诱发出胰岛素抵抗,给予小剂量链脲佐菌素(STZ)35mg/kg,腹腔注射,再给予普通饮食1个月,建立大鼠2型糖尿病免疫模型。结果:试验组大鼠血糖升高,空腹胰岛素降低,胰岛素敏感指数下降,胸腺指数降低,IL-6升高,IL-2降低,胸腺出现免疫病理改变,从生化及病理指标证实造模成功。结论:大鼠2型糖尿病免疫异常模型造模成功,是人2型糖尿病及其治疗研究的实验动物模型。 |
| 关 键 词： | 链脲佐菌素 大鼠 2型糖尿病免疫模型 |
Establishment of Models of Type 2 Diabetes Dysimmunity Induced by Streptozotocin in Rats |
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| XIE Ning,JING Hong-ying,WU Song,ZHENG Nan,ZHANG Liang. Establishment of Models of Type 2 Diabetes Dysimmunity Induced by Streptozotocin in Rats[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2011, 0(4): 5-6 | |
| Authors: | XIE Ning JING Hong-ying WU Song ZHENG Nan ZHANG Liang |
| Affiliation: | XIE Ning,JING Hong-ying,WU Song,ZHENG Nan,ZHANG Liang(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China) |
| Abstract: | Objective:To establish an animal model similar to human Type 2 diabetes dysimmunity.Methods:Male SD grown-up rats were fed with high-sugar and high-fat feeds to induce the insulin resistance and given lumbar injection of small dosage STZ 35mg/kg,and fed with general feeds for a month Models of Type 2 diabetes dysimmunity were established.Results:Blood sugar of rats in experimental group increased and their sensitivity to insulin dropped,fasting insulin dropped,IL-6 increased,IL-2 dropped,biochemistry target... |
| Keywords: | streptozotocin big mouse 2 diabetes dysimmunity models |
| 本文献已被 CNKI 等数据库收录！ | |