| Mindin is upregulated during colitis and may activate NF-κB in a TLR-9 mediated manner |
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| 作者姓名： | Bayasi Guleng |
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| 作者单位： | Division of Gastroenterology,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004, Fujian Province, China; Gastroenterology Institute of Xiamen University, Xiamen 361004, Fujian Province,China; Gastroenterology Center of Xiamen, Xiamen 361004, |
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| 基金项目： | Supported by National Natural Science Foundation of China,No. 30750013 |
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| 摘 要： | ![]()
AIM:To investigate the regulation of mindin expression and the signaling pathway involved during inflammation.METHODS:C57BL/6 mice were treated with 3% dextran sulfate sodium (DSS) in drinking water for 6 d to induce acute colitis,and then the colon was harvested for histological analysis or for RNA isolation.mRNA expression of mindin and nuclear factor (NF)-κB p65 was analyzed by quantitative real time polymerase chain reaction (RT-PCR) and mindin expression construct was conf irmed by Western blotting.Mou...
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| 关 键 词： | Nuclear factor-κB promoter activity |
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