子宫内膜增生的现代研究进展

子宫内膜增生是指从轻度可逆的腺性增生到癌前病变的一系列异质性病理改变。这一过程由一系列形态学上的变化构成,最早改变为单纯性腺体管状结构增生,该变化类似于增殖期子宫内膜细胞;病变进一步发展则为复杂性典型腺体增生,其细胞多出现核型异常类似于恶性子宫内膜样腺癌。早期的增殖范围可能仅限于子宫内膜局部,而进一步的增殖则可能扩散至整个子宫内膜。

The modern research of endometrial hyperplasia

Endometrial hyperplasia is a heterogeneous set of pathologic lesions that range from mild, reversible glandular proliferations to direct cancer precursors. These lesions comprise a continuum of morpho-logic appearances, with the earliest proliferation represented by crowded glands with simple tubular architecture lined by cells resembling proliferative endometrium, whereas advanced proliferations in this continuum are characterized by crowded glands with complex architecture, often containing cells with nuclear atypia resembling low-grade endometrioid adenocarcinoma. The former ＂early＂ prolifer-ations may be isolated to an endometrial polyp, but advanced proliferations are generally more dif- fusely present throughout the endometrium.