山豆根化学成分、药理作用及毒性研究进展

目的:介绍山豆根化学成分、药理作用及毒性研究进展。方法:查阅国内外相关资料并对其进行汇总、分析、综述。结果:至目前为止,已发现的化学成分主要有黄酮、生物碱、多糖等;药理毒理研究表明山豆根具有抗肿瘤、抗炎、抑菌、保肝、增强免疫、抗心律失常、降血压等药理活性,同时又可引起肝毒性、神经毒性、胃肠道反应等毒副作用。结论:建议开展山豆根抗肿瘤活性、毒性及肝毒性的"量-时-效"关系及作用机制研究,以及开展与之配伍减毒增效研究,建立其安全有效的治疗窗口,最终为其安全有效用药提供有意义的参考。

Research Progress in Chemical Components, Pharmacological Effectiveness and Toxicity of Radix et Rhizoma Sophorae tonkinensis

Objective: To introduce the research progress in chemical components, pharmacological actions and toxicity of Radix et Rhizoma Sophorae tonkinensis . Method: The relevant information and references were looked through, and further analyzed and reviewed. Result: Up to now, the chemical components isolated from S. tonkinensis include mainly flavonoids, alkaloids, polysaccharides, etc. Pharmacological references show that it has effects on antitumor, anti-inflammation, antimicrobial, hepatoprotection, immune stimulation, antiarrhythmia, antihypertension and so on. However, it may also induce toxicity such as hepatotoxicity, neurotoxicity, and gastrointestinal side effects. Conclusion: We should carry out further studies on mechanism-based antitumor activity and toxicity for the radix et rhizoma S. tonkinensis , to determine the safe and effective therapeutic window, and even to explore detoxification and enhancement actions by combing other medicines with it so to ensure its safe and effectiveness in clinic application.