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| 钩藤碱缓释滴丸的研制 | |
| 引用本文： | 周方勇,马静,骆科回. 钩藤碱缓释滴丸的研制[J]. 中国实验方剂学杂志, 2011, 17(4): 47-48 |
| 作者姓名： | 周方勇 马静 骆科回 |
| 作者单位： | 1. 贵州百花医药股份有限公司,贵州遵义,563000 2. 贵州省绥阳县人民医院,贵州绥阳,563300 |
| 摘 要： | 目的:优选钩藤碱缓释滴丸的制备工艺。方法:采用正交设计优化了药液温度、辅料用量比例及冷凝液温度和滴速等工艺条件,制备钩藤碱缓释滴丸,并初步研究其成型工艺。结果:所得缓释滴丸在pH 1.2盐酸和pH 6.8磷酸盐缓冲液及模拟胃肠道介质中的体外释药行为相似,不受pH变化影响。 |
| 关 键 词： | 钩藤碱 缓释滴丸 成型工艺 |
| 收稿时间： | 2010-03-15 |
Preparation of Rhynchophylline Sustained-release Dripping Pills |
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| ZHOU Fang-yong,MA Jing and LUO Ke-hui. Preparation of Rhynchophylline Sustained-release Dripping Pills[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(4): 47-48 | |
| Authors: | ZHOU Fang-yong MA Jing LUO Ke-hui |
| Affiliation: | 1.Guizhou Baihua Medical & Pharmaceutical Co.Ltd,Zunyi 563000,China;2.Guizhou Province Suiyang County People’s Hospital,Suiyang 563300,China) |
| Abstract: | Objective: To optimize the molding technology of rhynchophylline sustained-release dripping pills. Method: The Rhynchophylline sustained-release dripping pills were prepared.The technical parameters such as the temperature of liquid medicine,excipients proportion,speed of dripping and the temperature condensed fluid were optimized by orthogonal design. Result: The in vitro drug release behavior of the prepared products in pH 1.2 hydrochloric acid and pH 6.8 phosphate buffer solution was comparable,which indicated that the drug release behavior was pH-independent. |
| Keywords: | rhynchophylline sustained-release dripping pill formation |
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