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| 抗血小板凝集药物三氟柳的合成 | |
| 引用本文： | 段艳冰,刘实,陆晓和. 抗血小板凝集药物三氟柳的合成[J]. 中国实验方剂学杂志, 2011, 17(7): 80-81 |
| 作者姓名： | 段艳冰 刘实 陆晓和 |
| 作者单位： | 1. 解放军南京军区南京总医院,南京,210002;南京海陵中药制药工艺技术国家工程中心,南京,210049 2. 南京海陵中药制药工艺技术国家工程中心,南京,210049 3. 解放军南京军区南京总医院,南京,210002 |
| 摘 要： | 目的:合成抗血小板凝集药物三氟柳。方法:以三氟甲基水杨酸为原料通过一步合成目标产物三氟柳。结果:目标化合物通过核磁、质谱、红外、元素分析等进行结构鉴定,通过HPLC分析其纯度达99.5%以上,总收率达65.4%。结论:该方法合成简单,方法可行,适合工业化生产。 |
| 关 键 词： | 三氟柳 合成 结构鉴定 |
| 收稿时间： | 2010-09-02 |
Synthesis of Antiplatelet Drug Triflusal 1* |
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| DUAN Yan-bing,LIU Shi and LU Xiao-he. Synthesis of Antiplatelet Drug Triflusal 1*[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(7): 80-81 | |
| Authors: | DUAN Yan-bing LIU Shi LU Xiao-he |
| Affiliation: | Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China; Nanjing Hailing R&D for Chinese Traditional Medicine Pharmaceutical Technology, Nanjing 210049, China;Nanjing Hailing R&D for Chinese Traditional Medicine Pharmaceutical Technology, Nanjing 210049, China;Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China |
| Abstract: | Objective: To synthesis of the antiplatelet drug triflusal. Method: Triflusal was prepared from 4-trifluoro methyl salicylic acid by one step. Result: Its structure was confirmed by NMR, MS, IR, EA. The total yield of triflusal with the purity of 99.5% by HPLC was 65.4%. Conclusion: The synthetic route for triflusal was simple, feasible and convenient for industrial manufacture. |
| Keywords: | triflusal synthesis structural identification |
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