|
|||||
|
|
| 大鼠脑缺血不同时间脑能量代谢的变化研究 | |
| 引用本文： | 刘明,孙建宁,董世芬,刘洋,玄振玉.大鼠脑缺血不同时间脑能量代谢的变化研究[J].中国实验方剂学杂志,2011,17(5):216-218. |
| 作者姓名： | 刘明 孙建宁 董世芬 刘洋 玄振玉 |
| 作者单位： | 1. 北京中医药大学中药药理系,中药基础与新药研究实验室,北京,100102;贵阳中医学院,贵阳,550002 2. 北京中医药大学中药药理系,中药基础与新药研究实验室,北京,100102 3. 苏州玉森新药开发有限公司,江苏,苏州,215125 |
| 摘 要： | 目的:研究大鼠脑缺血不同时间脑能量代谢的变化。方法:复制大鼠永久性局灶性大脑中动脉缺血模型,测定缺血6,24,72,168,336 h脑组织乳酸(Lac)和丙酮酸(Pyru)的含量,Na+,K+-ATPase和Ca2+,Mg2+-ATPase活性。结果:在各个不同时间点,各检测指标与假手术组比较均具有显著性,P<0.05,P<0.01。结论:在缺血336 h内观测脑组织中能量代谢相关指标,可以用于评价药物对脑缺血的保护作用。 |
| 关 键 词： | 脑缺血 能量代谢 大鼠 |
| 收稿时间： | 9/3/2010 12:00:00 AM |
Changes in Brain Energy Metabolism for Different Duration of Cerebral Ischemia in Rats |
|
| LIU Ming,SUN Jian-ning,DONG Shi-fen,LIU Yang and XUAN Zhen-yu.Changes in Brain Energy Metabolism for Different Duration of Cerebral Ischemia in Rats[J].China Journal of Experimental Traditional Medical Formulae,2011,17(5):216-218. | |
| Authors: | LIU Ming SUN Jian-ning DONG Shi-fen LIU Yang and XUAN Zhen-yu |
| Institution: | Department of Traditional Chinese Medicine(TCM)Pharmacology,Beijing University of CM,Beijing 100102,China; Guiyang College of TCM,Guiyang 550002,China;Department of Traditional Chinese Medicine(TCM)Pharmacology,Beijing University of CM,Beijing 100102,China;Department of Traditional Chinese Medicine(TCM)Pharmacology,Beijing University of CM,Beijing 100102,China;Department of Traditional Chinese Medicine(TCM)Pharmacology,Beijing University of CM,Beijing 100102,China;Suzhou Yusen New Medicine Development,Co.Ltd,Suzhou 215125,China |
| Abstract: | Objective :To investigate changes in brain energy metabolism for different durations of cerebral ischemia in rats. Method: Permanent cerebral ischemia was induced by permanent middle cerebral artery occlusion(pMCAO) in rats,and ischemic cortex Lac and Pyru content,Na+,K+-ATPase and Ca2+,Mg2+-ATPase activity were measured at 6,24,72,168,336 h after ischemia. Result :At different time points after ischemia,brain energy metabolism in vehicle-treated rats showed significant changes compared with sham-operated group(P<0.05,P<0.01). Conclusion :There were fluctuation changes in ischemic cortex Lac and Pyru content,Na+,K+-ATPase and Ca2+,Mg2+-ATPase activity at different time points after ischemia in rats in vehicle-treated groups.Changes of ischemic cortex Lac and Pyru content,Na+,K+-ATPase and Ca2+,Mg2+-ATPase activity may be used as important indexes for early diagnosis and treatment assessment of cerebral ischemia. |
| Keywords: | cerebral ischemia energy metabolism rats |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 | |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 | |