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| 地黄饮子血清药物化学研究 | |
| 引用本文： | 郭司群,朱魁元,谢宁,姜媛媛,张宁. 地黄饮子血清药物化学研究[J]. 中国实验方剂学杂志, 2011, 17(8): 74-78 |
| 作者姓名： | 郭司群 朱魁元 谢宁 姜媛媛 张宁 |
| 作者单位： | 黑龙江中医药大学,哈尔滨,150040 |
| 摘 要： | 目的:对经方地黄饮子的血清药物化学进行研究。方法:利用UPLC-ESI-MS对地黄饮子体外样品及灌胃给予地黄饮子或单味药后家兔血清样品进行分析,比较各样品分析结果,确认地黄饮子的血中移行成分、代谢产物及其生药来源。结果:灌胃给予地黄饮子后家兔血清中发现9个血中移行成分,其中7个为新产生的代谢产物,2个为地黄饮子所含的原型成分,分别由五味子、远志、石菖蒲、巴戟天、山茱萸、肉苁蓉、附子、麦冬贡献产生。结论:初步确定了地黄饮子的血中移行成分及代谢产物,对其进行深入的研究,将助于阐明地黄饮子的有效成分及作用机制。 |
| 关 键 词： | 地黄饮子 血清药物化学 血中移行成分 |
| 收稿时间： | 2010-12-06 |
Serum Pharmacochemistry Study of Dihuang Yinzi |
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| GUO Si-qun,ZHU Kui-yuan,XIE Ning,JIANG Yuan-yuan and ZHANG Ning. Serum Pharmacochemistry Study of Dihuang Yinzi[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(8): 74-78 | |
| Authors: | GUO Si-qun ZHU Kui-yuan XIE Ning JIANG Yuan-yuan ZHANG Ning |
| Affiliation: | Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China |
| Abstract: | Objective: To investigate the parameters of serum pharmacochemistry of Dihuang Yinzi. Method: Using UPLC-ESI-MS method, the chromatograms of rabbit serum samples after oral administration of Dihuang Yinzi and crude drugs were analyzed and compared with control rabbit serum. Result: Nine constituents absorbed into the blood after administration of Dihuang Yinzi were detected, including seven metabolites and two original form compounds. Conclusion: The constituents absorbed into blood and their metabolites of Dihuang Yinzi were identified preliminary. This study is conducive to the exploration of bioactive constituents of Dihuang Yinzi. |
| Keywords: | Dihuang Yinzi serum pharmacochemistry constituents absorbed into blood |
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