五参顺脉胶囊对急性心肌梗死介入治疗后左室功能和QT间期离散度的研究

目的:观察五参顺脉胶囊对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)后左室功能和QT间期离散度(QTd)的影响。方法:98例AMI患者均行冠状动脉造影及PCI治疗,术后随机分为两组:对照组(48例)给予常规治疗;观察组(50例)给予常规治疗加五参顺脉胶囊口服。两组均连续治疗6个月。检测治疗前后左室射血分数(LVEF)、左室收缩末期容积(LVESV)、血浆B型尿钠肽(BNP)、标准12导联心电图。结果:治疗1个月后观察组的血浆BNP显著低于对照组(P<0.01);治疗6个月后,观察组LVEF显著高于治疗前和对照组(P均<0.01);观察组LVESV显著低于治疗前和对照组(P均<0.01);观察组QTcd显著低于治疗前和对照组(P<0.01,P<0.05);观察组心血管事件发生率显著低于对照组(P<0.05);观察组未发现任何不良反应。结论:五参顺脉胶囊可在常规治疗基础上显著改善AMI患者介入后的左室功能,降低血浆BNP水平,显著缩短QT间期离散度,减少心血管事件发生率,且安全性好。

Clinical Research of Wushen Shunmai Capsule on Left Ventricular Function and QT Interval Dispersion in Patients with Acute Nyocardial Infarction after Interventional Treatment

Objective: To observate the effect of Wushen Shunmai capsule on left ventricular function and QT interval dispersion in patients with acute myocardial infarction(AMI) after interventional treatment. Method: Ninety eight patients with AMI underwent coronary angiography and PCI treatment, were randomly divided into 2 groups, the control group (48 cases) treated with conventional therapy, the observation group (50 cases) received conventional therapy plus oral Wushen Shunmai capsule. Two groups were treated continuously for 6 months. Left ventricular ejection fraction, left ventricular end systolic volume, B-type natriuretic peptide(BNP), standard 12-lead ECG were detected before and after treatment. Result: After 1 month of treatment, the plasma BNP of the observation group was significantly lower than that of the control group(P <0.01).After 6 months of treatment, the LVEF of the observation group was significantly higher than that of before treatment and the control group(P <0.01); the LVESV of the observation group was significantly lower than that of before treatment and the control group (P <0.01); the QTcd of the observation group was significantly lower than that of before treatment and the control group(P <0.01, P <0.05); the incidence of cardiovascular events of the observation group was significantly lower than that of the control group(P <0.05); the observation group found no adverse reactions. Conclusion: Wushen Shunmai capsule significantly improved left ventricular function after percutaneous coronary intervention in patients with AMI on the basis of the conventional therapy, reduced BNP levels, shortened the QT interval dispersion significantly, to reduce the incidence of cardiovascular events with good.