双重血浆置换治疗吉兰巴雷综合征

目的：观察双重血浆置换(double filtration plasmapheresis，DFPP)对吉兰巴雷综合征(Guillain—Barre syndrome，GBS)的治疗效果．方法：6例吉兰巴雷综合征患进行双重血浆置换治疗，治疗前后观察神经功能改善状况，检测置换前后血液免疫系列、补体系列及置换后弃浆液的免疫系列、补体系列．结果：2例痊愈，3例好转、患血液中的补体及免疫球蛋白治疗后均明显下降、弃浆液补体及免疫球蛋白明显高于血液．结论：双重血浆置换是治疗重症吉兰巴雷综合征较为有效的方法、可能与降低血液中免疫球蛋白及补体有关．

Acute Guillain-Barre syndrome treated with double filtration plasmapheresis

AIM: To observe the effects of acute Guillain-Barre syndrome treated with double filtration plasmapheresis (DFPP). METHOD Six cases of acute Guillain-Barre syndrome were treated with DFPP. The change of neurological functions was observed before and after the treatment. The immunoglobulin and complement in blood were measured before and after therapy and in the discarded plasma. RESULTS: Two cases of the 6 were fully recovered and three cases were improved. Both immunoglobulin and complement in blood greatly decreased and both immunoglobulin and complement in discarded plasma were higher than those in blood. CONCLUSION: DFPP is effective in treating acute severe Guillain-Barre syndrome probably by lowering immunoglobulin and complement in blood.