ATP levels and glutathione regeneration in canine erythrocytes |
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| Authors: | M. Suzuki M. Abe M. Kurata N. S. Agar |
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| Affiliation: | (1) Japan Lyophilization Laboratory, 3-1-5 Matsuyama, Kiyose, Tokyo, Japan;(2) Department of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan;(3) Toxicology Research Laboratory, Chugai Pharmaceutical Co., 14016 Minowamachi, Kamiina-gun, 399-46 Nagano, Japan;(4) Department of Physiology, University of New England, Armidale, Australia |
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| Abstract: | ![]()
The effect of ATP levels on GSH regeneration was examined in canine erythrocytes. The main findings were: (1) The GSH regeneration was dependent on glucose and ATP; (2) cytochalasin B and polymyxin B, both glucose transport inhibitors, reduced ATP synthesis and GSH regeneration; (3) inosine, a substrate of the salvage pathway, was not effective for ATP synthesis and GSH regeneration. These results indicate that glucose transport and its metabolism play an important role in oxidant defence systems in general and GSH regeneration in particular in canine erythrocytes. |
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| Keywords: | ATP Dog Erythrocyte Glucose Glutathione Inosine |
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