Hypnoticlike effects of cannabidiol in the rat |
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| Authors: | Jaime M. Monti |
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| Affiliation: | (1) Departamento de Psicobiología, Escola Paulista de Medicina, São Paulo, Brasil;(2) Present address: Depto. de Farmacología y Terapéutica, Hospital de Clínicas, Montevideo, Uruguay |
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| Abstract: | The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats.During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects. |
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| Keywords: | Cannabidiol Cannabis sativa Slow-wave sleep Wakefulness |
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