血管内皮生长因子和微血管密度在涎腺腺样囊性癌中的表达及意义

目的:研究血管内皮生长因子和微血管密度在涎腺腺样囊性癌的表达及其与侵袭、转移等生物学行为的关系。方法:采用SP免疫组织化学染色的方法对40例涎腺腺样囊性癌组织中MVD和VEGF进行检测。结果:肿瘤组织中VEGF阳性表达率70％(28/40),MVD均值为(51.2±6.6),显著高于正常涎腺组织(P<0.05);VEGF高表达组的平均MVD值明显高于低表达组的平均MVD值(P

The Expression of Vascular Endothelial Growth Factor and Microvessel Density in Abenoid Cystic Carcinoma of Salivary Glands and Its Clinical Significance

Objective:To study the relationship between the expression of vascular endothelial growth factor and the microvessel density and invasion, metastasis in adenoid cystic carcinoma of salivary glands. Methods: Immunohistochemical staining( SP) was used to quantify MVD and VEGF expression in specimens from 40 patients with adenoid cystic carcinoma of salivary glands. Result: The positive expression rate of VEGF was 70% (28/40), the mean MVD was (51.2±6.6),the level of VEGF and MVD in adenoid cystic carcinoma of salivary glands was higher than in normal salivary glands tissue( P < 0.05) ; The mean MVD in case of high VEGF expression was significantly higher than those in cases of low VEGF expression( P < 0.05) . The distant metastasis rate in cases of high VEGF expression was significantly higher than those in cases of low VEGF expression( P < 0.05) . Conclusions: In adenoid cystic carcinoma of salivary glands, there is a significant positive correlation between MVD, VEGF and distant metastasis, MVD and VEGF may be served as a prognostic factor.