肝细胞移植治疗肝衰竭的研究进展

近年来许多研究证明肝细胞移植对急慢性肝衰竭有明显的治疗作用,是急慢性肝衰竭患者等待肝源、向原位肝移植过渡的有效方法。此文就肝细胞移植治疗肝衰竭的机制、肝细胞源、移植方式及实验和临床研究等方面的进展作了综述。

Hepatocyte transplantation for livelr failure: state of the art

In the last two decades,hepatocyte transplantation is proved to be an attractive therapy for liver failure alternative to liver transplantation and artificial liver.Hepatocyte transplantation has been successful in many animal models of acute liver failure,although only several clinical attempts have been made in human with encouraging but not yet convincing results,mainly because of the lack of a reliable source of live cells.Allogenic and xenogenic fresh or cryopreserved hepatocytes have been tested.Recent research has focused on fetal hepatocytes and progenitor liver cells of both hepatic and bone marrow origin.The ability to preserve and bank human hepatocytes would allow pooling of cells from multiple donors to increase the numbers for transplantation.The development of a reliable and large-scale available source of live cells would probably have a major impact on the introduction of hepatocyte transplantation in clinical practice.