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| 血管性痴呆大鼠海马一氧化氮合酶阳性神经元的变化 | |
| 引用本文： | 齐刚,张莉,宋月英,熊杰,李积胜.血管性痴呆大鼠海马一氧化氮合酶阳性神经元的变化[J].武警医学院学报,2001,10(2):91-92,95,F002. |
| 作者姓名： | 齐刚 张莉 宋月英 熊杰 李积胜 |
| 作者单位： | 1. 武警医学院中心实验室, 2. 武警医学院附属医院中医教研室, 3. 武警医学院解剖教研室, |
| 摘 要： | 目的：观察血管性痴呆大鼠海马神经元型一氧化氮合酶（nNOS)阳性神经元的变化。方法：采用改良的Pulsinelli4-血管阻断（4－VO）方法建立大鼠血管性痴呆模型，用免疫组化法研究大鼠海马nNOS的表达的变化。结果：与正常对照组比较，血管性痴呆大鼠海马CA1区和CA3区nNOS阳性神经元数目明显减少。结论：血管性痴呆大鼠海马nNOS阳性神经元的数目减少，与血管性痴呆的形成有关。 |
| 关 键 词： | 血管性痴呆 海马 一氧化氮合酶 阳性神经元 大鼠 nNOS |
| 文章编号： | 1008-5041(2001)02-0091-02 |
Changes of the expression of neuronal nitric oxide synthase (nNOS) positive neurons of hippocampus in vascular dementia rats |
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| QI Gang,ZHANG Li,SONG Yue-ying,et al..Changes of the expression of neuronal nitric oxide synthase (nNOS) positive neurons of hippocampus in vascular dementia rats[J].Acta Academiae Medicinae CPAPF,2001,10(2):91-92,95,F002. | |
| Authors: | QI Gang ZHANG Li SONG Yue-ying |
| Institution: | QI Gang,ZHANG Li,SONG Yue-ying,et al.Central Laboratory,Medical College of Chinese People's Armed Police Forces.Tianjin 300162 |
| Abstract: | Objective:To observe the changes of the expression of neuronal nitric oxide synthase(nNOS)positive neurons of hippocampus in vascular dementia of rats.Methods:Modified Pulsinelli's 4-vessel occlusion(4-VO)method was used to establish the model of vascular dementia(VD)in rats.Immunohistochemical method was used to investigate the expression of (nNOS)in different subfields of hippocampus in vascular dementia rats.Results:The number of nNOS positive neurons decreased significantly in the areas of hippocampus of VD group the normal control group.Conclusion:The decreased expression of nNOS positive neurons plays an important role in the process of vascular dementia formation. |
| Keywords: | Dementia Vascular Hippocampus Nitric oxide synthase |
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