|
|||||
|
|
A comparison of multiple urine markers for interstitial cystitis |
|
| Authors: | Erickson Deborah R Xie Sharon X Bhavanandan Veer P Wheeler Marcia A Hurst Robert E Demers Lawrence M Kushner Leslie Keay Susan K |
| Affiliation: | aFrom the Division of Urology and Departments of Health Evaluation Sciences, Biochemistry and Medicine and Pathology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, Section of Urology, Yale School of Medicine, New Haven, Connecticut, Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York, and Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland |
| Abstract: | PURPOSE: We measured several urine markers in 24-hour specimens from patients with interstitial cystitis and healthy controls. For each marker we determined whether the urine level was significantly different in interstitial cystitis and control cases, and whether the marker level correlated with the symptom score. MATERIALS AND METHODS: Study participants included 36 female patients with interstitial cystitis and 36 age matched female volunteers. Multiple urine aliquots were obtained to measure the various markers. RESULTS: Certain markers were significantly increased in interstitial cystitis, including anti-proliferative factor, epidermal growth factor, insulin-like growth factor (IGF) binding protein-3 and interleukin (IL)-6. Markers significantly decreased in interstitial cystitis were heparin-binding epidermal growth factor-like growth factor, cyclic guanosine monophosphate and methylhistamine. Other markers were not significantly different in the interstitial cystitis and control groups, including total glycosaminoglycans, epitectin, hyaluronic acid, IL-8, IL-1 and nitrates plus nitrites. IGF-1 was undetectable in 24-hour urine samples but spot voided samples from the same interstitial cystitis population had IGF-1 levels similar to previously reported levels. The only significant association of marker with symptom score was a positive correlation of IL-6 with nocturia. For all markers the conclusions were the same whether the marker was normalized to creatinine or to 24 hours. CONCLUSIONS: This study confirmed several previously reported urine alterations in interstitial cystitis, including increased anti-proliferative factor, epidermal growth factor, IGF binding protein-3 and IL-6, and decreased heparin-binding epidermal growth factor-like growth factor and cyclic guanosine monophosphate. Of all markers studied anti-proliferative factor had the least overlap in the interstitial cystitis and control groups, and so it is the most likely candidate to become a diagnostic test. |
| Keywords: | bladder cystitis, interstitial growth substances biological markers signs and symptoms |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |