高频振荡通气治疗新生儿呼吸窘迫综合征的临床对照研究

目的　观察高频振荡通气 (HFV)对新生儿呼吸窘迫综合征 (NRDS)的治疗效果。　方法　采用高频振荡通气治疗 NRDS患儿 2 5例 ,并与同期一般常规通气治疗的 2 5例 NRDS患儿进行前瞻性临床对照研究。　结果　察组存活 2 0例 ,并发肺炎 12例 ,脑室内出血 (IVH ) 3例 ,肺出血4例 ,动脉导管未闭 (PDA) 4例 ,支气管 -肺发育不良 (BPD) 2例 ,无气漏发生 ;死亡 5例。存活儿使用呼吸机平均时间 88.6 h。对照组存活 14例 ,并发肺炎 12例 ,IVH 3例 ,肺出血 11例 ,PDA 8例 ,BPD6例 ,气漏 3例 ,死亡 11例。存活儿平均呼吸机使用时间为 15 4.7h。　结论　高频振荡通气可有效地减少了气压伤 ,缩短了使用呼吸机的时间 ,较常频呼吸机使用更为安全。

Outcome of Neonatal Respiratory Distress Sydrome Treated with High Freguency Ventilation

Objective To study the outcome of NRDS treated with HFV. Methods The study was a prospective controlled clinical trial. Twenty-five newborns with NRDS were treated with HFV and another 25 treated with normal frequency ventilation were served as control. Results Twenty newborn infants survived in HFV group, and complicated with neonatal pneumonia in 12, intraventricular hemorrhage in 3, neonatal pulmonary hemorrhage in 4, patent ductus arteriosus in 4, broncho-pulmonary dysplasia in 2, and air Leak in 3. Fourteen newborn infants were survived in control group, and complicated with neonatal pneumonia in 12, patent ductus arteriosus in 8, intraventricular hemorrhage in 4, neonatal pulmorary hemorrhage in 11, broncho-pulmonany in 6, and air Leak in 3. The mean time of mechanical ventalation was 88.6 hrs in survivors of HFV group vs. 154.7 hrs in that of control group. Conclusions The HFV can reduce the mean time used for mechanical ventilation, and it is as safe as normal-frequency ventilation.