| 盐酸丁咯地尔缓释片的制备及体外释放度研究 |
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| 引用本文： | 常建晖,于孝堂,邓树海,贾孟良. 盐酸丁咯地尔缓释片的制备及体外释放度研究[J]. 中国医药工业杂志, 2002, 33(6): 286-287,290 |
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| 作者姓名： | 常建晖 于孝堂 邓树海 贾孟良 |
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| 作者单位： | 1. 山东大学药学院,山东济南,250012
2. 威海市立医院药剂科,山东威海,264200 |
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| 摘 要： | 以羟丙甲纤维素和丙烯酸树脂为骨架材料，5％乙基纤维素乙醇溶液作为粘合剂，采用湿法制粒压片，制备盐酸丁各地尔缓释片，进行体外释放度试验，并与进口缓释片进行比较。结果表明：研制缓释片的缓释效果良好，药物的释放符合一级动力学规律。
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| 关 键 词： | 盐酸丁咯地尔缓释片 制备 体外释放度 羟丙甲纤维素 丙烯酸树脂 动脉血管活性剂 |
| 文章编号： | 1001-8255(2002)06-0286-03 |
Preparation and in vitro Release of Buflomedil Hydrochloride Sustained-release Tablets |
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| CHANG Jian Hui ,YU Xiao Tang ,DENG Shu Hai ,JIA Meng Liang. Preparation and in vitro Release of Buflomedil Hydrochloride Sustained-release Tablets[J]. , 2002, 33(6): 286-287,290 |
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| Authors: | CHANG Jian Hui YU Xiao Tang DENG Shu Hai JIA Meng Liang |
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| Affiliation: | CHANG Jian Hui 1,YU Xiao Tang 2,DENG Shu Hai 1,JIA Meng Liang 1 |
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| Abstract: | With hydroxypropylmethylcellulose and Eudragit RS PO as carriers, and 5% ethanolic ethylcellulose solution as adhesive, buflomedil hydrochloride sustained release tablets were prepared by wetting granulation method. The release rates of the tablets were determined and compared with imported sustained release tablets. The results indicated that the sustained release tablets had an expected sustained release quality, and the drug release pattern was in accorded with the first order kinetics. |
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| Keywords: | buflomedil hydrochloride sustained release tablets hydroxypropylmethylcellulose(HPMC) Eudragit RS PO |
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