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| ENA-78在子宫内膜异位症患者卵泡液中的表达 | |
| 引用本文： | 张岭梅,刘风华,王沂峰,姚吉龙. ENA-78在子宫内膜异位症患者卵泡液中的表达[J]. 广州医学院学报, 2012, 40(4): 5-7 |
| 作者姓名： | 张岭梅 刘风华 王沂峰 姚吉龙 |
| 作者单位： | 张岭梅 (深圳市妇幼保健院妇科,广东深圳,518028) ； 刘风华 (广东省妇幼保健院生殖科,广东广州,510100) ； 王沂峰 (南方医科大学附属珠江医院妇科,广东广州,510282) ； 姚吉龙 (深圳市妇幼保健院妇科,广东深圳,518028) ； |
| 基金项目： | 广东省科学技术研究基金,深圳市科技计划项目 |
| 摘 要： | 目的：了解子宫内膜异位症患者卵泡液微环境变化。方法：选择2009年12月至2011年8月于深圳市妇幼保健院行IVF／ICSI-ET的36例子宫内膜畀位症患者作为研究组，同期输卵管因素不孕患者46例作为对照组。采用酶联免疫吸附法测定两组患者卵泡液中上皮中性粒细胞活化肽-78（ENA-78）水平。结果：研究组患者卵泡液ENA-78水平（184．59±65．10）pg／mL明显高于对照组（139．62±58．38）pg／mL，差异有统计学意义（P〈0．05）。结论：子宫内膜异位症患者卵泡液中ENA-78水平较输卵管因素不孕患者升高，其高水平的ENA-78可能是子宫内膜异住症患者卵母细胞质量下降、受精能力受损的原因之一。 |
| 关 键 词： | 子宫内膜异位症 卵泡液 上皮中性粒细胞活化肽-78 |
Expression and significance of epithelial neutrophil-activating peptide-78 in follicular fluid in patients with endometriosis |
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| ZHANG Ling-mei,LIU Fertg-hua,WANG Yi-feng,YAO Ji-long. Expression and significance of epithelial neutrophil-activating peptide-78 in follicular fluid in patients with endometriosis[J]. Academic Journal of Guangzhou Medical College, 2012, 40(4): 5-7 | |
| Authors: | ZHANG Ling-mei LIU Fertg-hua WANG Yi-feng YAO Ji-long |
| Affiliation: | 1 Department of Gynecology, Shenzhen Maternal and Child Health Care Hospital, Shenzhen 518028, Guangdong ; Z Center of reproductive medicine, Guangdong Maternal and Children Hospital, Guangzhou 510100;3Department of Gynecology, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong , China) |
| Abstract: | Abstract Objective： To assess the changes in microenvironment of follicular fluid in patients with endometriosis. Methods：Thirty-six patients with endometriosis who received in vitro fertilization-embryo transfer between December 2009 to August 2011 in Shenzhen Maternal and Child Health Care Hospital and 46 patients with tubal-associated infertility were allocated in study group and control group, respectively. The level of epithelial neutrophil-activating peptide-78 （ENA-78） in follicular fluid was measured by using enzyme-linked immunosorbent assay （ELISA）. Results： Mean ENA-78 concentration in study group was significantly higher than that in control group E （ 184.59 ± 65.10） pg/mL vs （ 139.62 ± 58.38 ） pg/mL,P 〈 0.05 ]. Conclusion： Patients with endometriosis may present higher level of ENA-78 in follicular fluid than those with tubal-associated infertility. Increased ENA-78 level may be one of the causes of poorer quality and lower fertility of ooeytes in patients with endometriosis. |
| Keywords: | endometriosis follicular fluid epithelial neutrophil-activating peptide-78 |
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