| 氧甲吡嗪治疗高脂血症的临床观察 |
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| 引用本文： | 寇文镕,陆宗良,徐义枢,陶萍,陈在嘉. 氧甲吡嗪治疗高脂血症的临床观察[J]. 中国循环杂志, 1992, 0(1) |
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| 作者姓名： | 寇文镕 陆宗良 徐义枢 陶萍 陈在嘉 |
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| 作者单位： | 中国医学科学院心血管病研究所、阜外医院(寇文镕，陆宗良，徐义枢，陶萍)，中国医学科学院心血管病研究所、阜外医院(陈在嘉) |
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| 摘 要： | 75例高脂血症患者按血脂水平以2∶1配对随机分组,50例服氧甲吡嗪,25例服非诺贝特作为对照。12周后两组血清总胆固醇与甘油三酯下降,高密度脂蛋白胆固醇升高均较治疗前有明显差异。氧甲吡嗪降甘油三酯作用不如对照组,但副作用较少。
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| 关 键 词： | 氧甲吡嗪 非诺贝特 胆固醇 甘油三酯 高密度脂蛋白胆固醇 |
A COMPARATIVE STUDY ON THE EFFECTS OF OLBETAM AND FENOFIBRATE IN HYPERLIPIDEMIA |
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| Kou Wenrong,Lu Zongliang,Xu Yishu,et al.. A COMPARATIVE STUDY ON THE EFFECTS OF OLBETAM AND FENOFIBRATE IN HYPERLIPIDEMIA[J]. Chinese Circulation Journal, 1992, 0(1) |
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| Authors: | Kou Wenrong Lu Zongliang Xu Yishu et al. |
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| Affiliation: | Kou Wenrong,Lu Zongliang,Xu Yishu,et al. Cardiovascular Institute and Fu Wai Hospital,CAMS,Beijing |
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| Abstract: | Olbetam (5-methylpyrazine carboxylic acid 4-oxide), an analogue of nicotinic acid, is a new blood lipid modulator. A comparative study on the effects of olbetam (750mg/day) in 55 patients and fenofibrate (300mg/day) in 25 patients with hyperlipidemia was carried out. At the end of a 12 week trial, serum total cholesterol (TC) decreased by 9.2% (P<0.001) with olbetam and 16.2% (P<0.001) with fenofibrate,serum triglyceride (TC) decreased by 27.5% (P<0.001) and 52.8% (P<0.001) respectively. It also caused a statistically significant increase in high density lipoprotein cholesteral (HDL-C) by 19.2% and 30.7% respectively. No significant differences between both groups in TC, TG and HDL-C were observed. The side effect of oibetam was less than that of fenofibrate. It is suggested that olbetam is an effective and tolerable lipid modulator. |
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| Keywords: | Olbetam Fenofibrate Cholesterol Triglyceride High density lipoprotein cholesteral |
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