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| 胰高血糖素样肽-1对糖尿病心血管病变的影响 | |
| 引用本文： | 杨淑芬,陈红梅. 胰高血糖素样肽-1对糖尿病心血管病变的影响[J]. 临床药物治疗杂志, 2016, 0(1): 17-20. DOI: 10.3969/j.issn.1672-3384.2016.01.004 |
| 作者姓名： | 杨淑芬 陈红梅 |
| 作者单位： | 1. 汕头大学医学院,汕头,515041;2. 广东省人民医院内分泌科，广东省医学科学院，广州 510080 |
| 基金项目： | 广东省药学会2型糖尿病用药研究基金项目(2012C15) |
| 摘 要： | 目的:综述近年胰高血糖素样肽1及其类似物的研究进展,为糖尿病心血管病变的临床防治提出新的思路。方法:通过检索近10余年的相关文献,总结胰高血糖素样肽1及其类似物对糖尿病心血管病的作用及其相关机制。结果结论:目前研究提示胰高血糖素样肽1除了可以有效降低血糖以外,还通过多种机制影响心脏和血管的功能,此类活性物质以其独特的作用机制,为糖尿病心血管病变的治疗掀开新的一页。 |
| 关 键 词： | 胰高血糖素样肽1 糖尿病 心血管系统 |
Effect of Glucagon-like peptide-1 on cardiovascular disease in Type 2 diabetes patients |
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| Abstract: | Objective:Recent studies demonstrate glucagon-like peptide-1 and its analogs have the cardioprotection effect, and provid new options of treatment for patients with diabetic cardiovascular disease.Methods: Relevant information was identiifed through a literature research of PubMed, the cardiovascular protective effect and its related mechanism of glucagon-like peptide-1were summarized. Results and Conclusion: Besides glycemic control, cardioprotection effect of glucagon-like peptide-1 and its analogs via different pathways were conifrmed, which is beneifcial to searching new strategies for patients with diabetic cardiovascular disease. |
| Keywords: | glucagon-like peptide-1 diabetes mellitus cardiovascular system |
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