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Pulsatile release of catecholamines in the hypothalamus of conscious rats
Authors:H. Dietl  H. Prast  A. Philippu
Affiliation:(1) Institut fur animalische Physiologie, Universitat Bayreuth, Bayreuth, Federal Republic of Germany;(2) Institut fur Pharmakologie and Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria
Abstract:
Summary To investigate the patterns of catecholamine release in the brain, the hypothalamus of conscious, freely moving rats was superfused through a push-pull cannula with artificial cerebrospinal fluid and the catecholamines dopamine, noradrenaline and adrenaline were determined in the superfusate radioenzymatically. Superfusate was continuously collected in time periods of 20 min for at least 20h. Dopamine, noradrenaline and adrenaline release rates fluctuated according to an ultradian rhythm with a frequency of 1 cycle/92 min (dopamine and noradrenaline) or 99 min (adrenaline). Additionally, the three catecholamines were released according to an ultradian rhythm with the following frequencies: noradrenaline and adrenaline 1 cycle/ 12 h, dopamine 1 cycle/8 h. The release rates of dopamine and adrenaline were similar during light and dark periods, while the release rate of noradrenaline in the dark period was slightly lower than that during the light period. It is concluded that in the hypothalamus of the conscious rat the release rates of dopamine, noradrenaline and adrenaline fluctuate according to two ultradian rhythms with different frequencies.This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds zur Förderung der wissenschaftlichen ForschungParts of this work have been presented at the 29th Spring Meeting of the German Society of Pharmacology and Toxicology, 1988 and at the 12th Annual Meeting of the European Neuroscience Association, 1989Correspondence to H. Prast at the above address
Keywords:Ultradian rhythm  Hypothalamus  Pushpull cannula  Dopamine  Noradrenaline  Adrenaline
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