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| 乙醇脱氢酶2和乙醛脱氢酶2基因多态性及饮酒习惯与直肠癌易感性的研究 | |
| 引用本文： | 姜爱仁,高长明,吴建中,曹佳,Tajima Ka-zuo,沈洪兵.乙醇脱氢酶2和乙醛脱氢酶2基因多态性及饮酒习惯与直肠癌易感性的研究[J].中华肿瘤防治杂志,2007,14(19):1445-1449. |
| 作者姓名： | 姜爱仁 高长明 吴建中 曹佳 Tajima Ka-zuo 沈洪兵 |
| 作者单位： | 1. 南京医科大学肿瘤中心,江苏省肿瘤防治研究所,江苏,南京,210009 2. 日本鹿儿岛大学医学部岛屿医学教研室,鹿儿岛,890-8544,日本 3. 中国人民解放军第三军医大学军事预防医学院,重庆,500038 4. 日本爱知县癌中心研究所疫学预防部,名古屋,464-8681,日本 5. 南京医科大学肿瘤中心,江苏省肿瘤防治研究所,江苏,南京,210009;南京医科大学公共卫生学院流行病与卫生统计学系,江苏,南京,210029 |
| 基金项目： | 日本文部省科研项目;中国国家自然科学基金重大国际(地区)合作研究项目 |
| 摘 要： | 目的:研究乙醇脱氢酶2(ADH2)、乙醛脱氢酶2(ALDH2)基因多态性与直肠癌易感性的关系。方法:采用病例-对照研究方法,以PCR-DH-PLC检测研究对象的ADH2/ALDH2基因型,比较不同的基因型及生活习惯与直肠癌的关系。结果:1)与不饮酒者相比较,饮酒者患直肠癌的危险性显著增高(OR=2.20,95%CI:1.47～3.28,P=0.000);2)多因素分析结果未发现ADH2、ALDH2各基因型与直肠癌的危险性有关。3)对ADH2、ALDH2基因多态相互作用的分层分析发现,同时携带ADH2A/A和ALDH2G/G基因型者,发生直肠癌的危险性显著增高(性别、年龄和吸烟调整OR=1.82,95%CI:1.07～3.09)。4)在饮酒者中,ADH2A/A、A/G G/G基因型者患直肠癌的调整OR分别为2.56(95%CI:1.38～4.73)和2.10(95%CI:1.15～3.84);ALDH2G/G基因型者发生直肠癌的调整OR为1.82(95%CI:1.07～3.09)。结论:饮酒是直肠癌的危险因素;ADH2A/A与ALDH2G/G基因型在增加直肠癌易感性上有协同作用;ALDH2G/A A/A基因型可减弱饮酒患直肠癌的危险性。 |
| 关 键 词： | 直肠肿瘤 乙醇脱氢酶2 乙醛脱氢酶2 基因多态性 病例对照研究 |
| 文章编号： | 1673-5269（2007）19-1445-05 |
| 收稿时间： | 2006-11-29 |
| 修稿时间： | 2007-03-25 |
Association between ADH2/ALDH2 genetic polymorphism and habit of alcohol drinking and the susceptibility of rectal cancer |
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| JIANG Ai-ren,GAO Chang-ming,WU Jian-zhong,Takezaki Toshiro,CAO Jia,Tajima Ka-zuo,SHEN Hong-bing.Association between ADH2/ALDH2 genetic polymorphism and habit of alcohol drinking and the susceptibility of rectal cancer[J].Chinese Journal of Cancer Prevention and Treatment,2007,14(19):1445-1449. | |
| Authors: | JIANG Ai-ren GAO Chang-ming WU Jian-zhong Takezaki Toshiro CAO Jia Tajima Ka-zuo SHEN Hong-bing |
| Institution: | 1. Cancer Center of Nanjing Medical University ,J iangsu Province Institute of Cancer Research, Nanjing 210009, P.R. China; 2. Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan ;3. School of Military Prevention Medicine, Third Military Medical University, Chongqing 400038, P. R. China ;4. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan; 5. School of Public Health, Nanjing Medical University, Nanjing 210029, P. R. China |
| Abstract: | OBJECTIVE:To study the association between ADH2/ALDH2 genetic polymorphism and habit of alcohol drinking and the susceptibility of rectal cancer.METHODS:A case control study was conducted with 210 patients with rectal cancer and 439 population based controls in Jiangsu Province,China.ADH2 and ALDH2 genotypes were detected by PCR-DHPLC.RESULTS:1)Alcohol drinking was associated with the increased risk of rectal cancer(adjusted OR=2.20,95%CI:1.47-3.28).2)Individuals with ADH2 A/A and ALDH2 G/G genotypes had an elevated risk with rectal cancer(adjusted OR=1.82,95%CI:1.07-3.09).3)Drinkers with ADH2 A/A or A/G G/G and those with ALDH2 G/G were at a significantly risk of developing rectal cancer(adjusted ORADH2 A/A=2.56,95%CI:1.38-4.73,ORADH2 A/G G/G=2.10,95%CI:1.15-3.84,ORALDH2=2.63,95%CI:1.53-4.52).CONCLUSION:Alcohol drinking might be a risk factor of rectal cancer,and the interaction might exist between polymorphisms of ADH2 A/A and ALDH2 G/G.ALDH2A allele may be a decreased risk factor of rectal cancer. |
| Keywords: | rectal neoplasms alcoholdehy drogenase 2 aldehydede hydrogenase2 polymorphism case-control study |
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