| p53-Ser~(392)的磷酸化在肿瘤治疗中的作用 |
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| 引用本文： | 刘景利,石新丽,崔澂,任来峰,郑文广,李明远.p53-Ser~(392)的磷酸化在肿瘤治疗中的作用[J].解剖学报,2014,45(3):437-440. |
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| 作者姓名： | 刘景利 石新丽 崔澂 任来峰 郑文广 李明远 |
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| 作者单位： | 1. 白求恩医务士官学校医学技术系，石家庄 050081; 2. 河北中医学院教务处，石家庄 050200;3.山西医科大学汾阳学院医学检验系，山西 汾阳 032200; 4 四川大学华西基础医学与法医学院， 成都 610041 |
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| 摘 要： | 磷酸化是p53转录后修饰最常见的方式,但对p53-Ser392的磷酸化在肿瘤治疗中的作用及具体机制知之甚少。我们就p53-Ser392的磷酸化状态对野生型及突变型p53功能的影响、放疗化疗因素及蛋白激酶对p53-Ser392的磷酸化水平的调节和p53-Ser392的磷酸化研究意义进行了阐述。
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| 关 键 词： | p53 Ser392 磷酸化 肿瘤治疗 基因定点突变 免疫印迹法 |
| 收稿时间： | 2013-10-17 |
Role of phosphorylation of p53 at Ser392 in cancer therapy |
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| LIU Jing-li,SHI Xin-li,CUI Cheng,REN Lai-feng,ZHENG Wen-guang,LI Ming-yuan.Role of phosphorylation of p53 at Ser392 in cancer therapy[J].Acta Anatomica Sinica,2014,45(3):437-440. |
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| Authors: | LIU Jing-li SHI Xin-li CUI Cheng REN Lai-feng ZHENG Wen-guang LI Ming-yuan |
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| Institution: | 1. Department of Repairing and Servicing Technology of Medical Equipment, Bethune Medical Non Commissioned Officer Academy of PLA, Shijiazhuang 050081, China;2. Academic Affairs Office, Hebei University of Chinese Medicine，Shijiazhuang 050200, China;3. Department of Medical Laboratory Science, Fenyang College of Shanxi Medical University, Shanxi Linfen 032200, China;4. Department of Microbiology, College of Basic and Forensic Medicine, Sichuan University, Chengdu 610041, China);
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| Abstract: | Phosphorylation is the most common way of p53 post-translational modifications. However, gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p53 at Ser392 in carcinogenesis and cancer prevention. In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase, and the significance of phosphorylation of p53-Ser392 in cancer treatment. |
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| Keywords: | p53 Ser392 Phosphorylation Cancer therapy Gene mutant Western blotting |
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