| 拉米夫定耐药患者临床指标变化特点 |
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| 引用本文： | 孙剑,徐朝艳,陈金军,王战会,侯金林.拉米夫定耐药患者临床指标变化特点[J].现代临床医学,2007,33(3):163-164. |
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| 作者姓名： | 孙剑 徐朝艳 陈金军 王战会 侯金林 |
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| 作者单位： | 南方医科大学南方医院,广东广州,510515;中山大学第一附属医院,广东广州,510080 |
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| 摘 要： | 目的:观察拉米夫定治疗过程中发生耐药的慢性乙肝患者的临床特点.方法:分析在我科接受拉米夫定治疗的247例慢性乙肝患者的临床资料及治疗过程中肝功能及HBV DNA水平的变化,并对发生YMDD变异的患者临床特点进行总结.结果:247例患者中有42例发生YMDD变异,其中有28例患者出现肝炎突发,36例患者出现:HBV DNA反跳,但发生YMIDD变异后平均HBV DNA水平仍低于治疗前(P＜0.05),谷丙转氨酶(ALT)水平与治疗前相比无明显差异(P＞0.05).结论:拉米夫定长期治疗过程中慢性乙肝患者耐药性的产生及由此引发的部分患者肝功能和病毒水平的反跳应引起临床医生的密切关注.
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| 关 键 词： | 拉米夫定 耐药 临床特点 |
| 文章编号： | 1673-1557(2007)03-0163-02 |
| 修稿时间： | 2007年4月6日 |
Characteristics of Clinical Parameters of Patients with Lamivudine Resistance |
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| SUN Jian,XU Chao-yan,CHEN Jin-jun,WANG Zhan-hui and Hou Jin-lin.Characteristics of Clinical Parameters of Patients with Lamivudine Resistance[J].Journal of Modern Clinical Medicine,2007,33(3):163-164. |
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| Authors: | SUN Jian XU Chao-yan CHEN Jin-jun WANG Zhan-hui and Hou Jin-lin |
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| Abstract: | Objective:To explore the clinical characteristics of patients with lamivudine resistance.Methods:Two hundred and forty-seven chronic hepatitis B patients treated with lamivudine were included in this study.The liver function and HBV DNA level were analyzed.Results:Lamivudine resistance mutant(YMDD mutant) developed in forty-two out of two hundred and forty-seven patients.Among them,hepatitis flare and DNA rebound occurred in twenty-eight and thirty-six patients respectively.After emergence of YMDD mutant,the mean HBV DNA level was still lower than that of baseline(P<0.05),the ALT level was not different from that of baseline(P>0.05).Conclusion:We should pay attention to the emergence of lamivudine resistance and the hepatitis flare and DNA rebound in these patients. |
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| Keywords: | lamivudine resistance clinical characteristics |
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