善得定诱导卡铂腹腔淋巴化疗的实验研究

 为探讨善得定对腹腔化疗中淋巴药物浓度的影响,对16只兔腹腔注入卡铂50mg十生理盐水100ml,实验组加用善得定,分取门静脉血、外周血、淋巴液,应用原子吸收光谱法测定样本铂浓度.结果显示:实验组淋巴铂浓度达峰后可维持较高水平,其药-时曲线下面积(AUC)显著增加.外周血铂浓度却下降明显.提示:在卡铂腹腔化疗中应用善得定能提高化疗药物在淋巴中的作用效能,达到诱导腹腔淋巴化疗的目的.同时又可进-步减轻化疗药物的全身毒副反应.

Sandostatin modulation of lymphatic drug exposure following intraperitoneal administration of carboplatin

To examine the effect of sandostatin to lymph drug concntration following intraperitoneal(IP)chemotherapy,50mg carboplat was injected into Rabbits IP along with 20ug/h sandostatin as a continous Ⅳ infusion in one group and no sandostatin in the control group.The platinum in lym-ph,jugular vein and protal vein over the ensuring 8 hous were measured by the flameless atomic abshaption spectoscopy.The result show:for the experimental whinals,the Platinum in lymph remain a higher level even after reaching the peak concenhation,result in the increasing of AUC(0- 8)(P<0.01).In contrast,it kept on decreasing in jugular vein(P<0.01).This Permitted an indirect estimate of the effect of sand-ostatin on the rate of carboplatin movement from the peritoneal cavity to the local lymph,so become the candidate to induce intra-abdominal lymphatic chemotherapy with more lower system reaction.