Hereditary Hypertriglyceridemic Rat: A New Animal Model of Metabolic Alterations in Hypertension |
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Authors: | Iwar Klime Antonian Vraana Jaroslav Kune Elena eboUkovaA Zdena Dobe ovaa Pavel tolba Josef Zicha |
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Affiliation: | a Diabetes and Nutrition Research Laboratory, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republicb Department of Metabolic Research, Institute for Clinical and Experimental Medicine, CZ, Prague-4c Institute of Physiology, Academy of Sciences of the Czech Republic, CZ, Prague-4d Department of Biochemical Endocrinology, Research Institute of Endocrinology, CZ, Prague-1 |
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Abstract: | Hereditary hypertriglyceridemic rats (hHTg) were developed as a new genetic model for the study of relationships between blood pressure (BP) and metabolic abnormalities. This strain has been produced by selective inbreeding from Wistar rats according to the rise of plasma triglycerides induced by a high-sucrose diet. Though hHTg rats display hypertriglyceridemia, impaired glucose tolerrance, hyperinsulinemia, insulin resistance and increased BP even without nutritional stimuli, high sucrose feeding further aggravates these symptoms. High plasma triglycerides levels in hHTg rats seem to be a consequence of their hyperproduction. Impaired insulin action is responsible for the defective glucoregulation in this strain. The loss of insulin responsiveness might be due to a reduction in the number of glucose transporters. Highly significant relationships among plasma triglycerides, ouabain-resistant Na+ transport and BP were demonstrated in the hHTg rats. Segregating populations (F2 hybrids) should be used for genetic analysis of the primary role of lipid and/or ion transport abnormalities in the pathogenesis of this form of genetic hypertension. |
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Keywords: | hereditary hypertriglyceridemic rat insulin resistance glucose transport omega-3 polyunsaturated fatty acids blood pressure ion transport |
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