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| 载脂蛋白E基因表型与慢性硬膜下血肿关系的初步研究 | |
| 引用本文： | 徐震,顾志恺. 载脂蛋白E基因表型与慢性硬膜下血肿关系的初步研究[J]. 中国交通医学杂志, 2006, 20(2): 177-178 |
| 作者姓名： | 徐震 顾志恺 |
| 作者单位： | 南通大学附属医院神经外科,江苏,226001;南通大学附属医院神经外科,江苏,226001 |
| 摘 要： | 目的:探讨载脂蛋白E基因表型与慢性硬膜下血肿(CSDH)的关系。方法:采用聚合酶链—限制性片段长度多态性(PCR-RFLP)方法,对65例CSDH患者外周血的ApoE基因型进行分析。结果:65例患者ApoE基因型分别为E2/E26例、E3/E314例、E4/E48例、E2/E37例、E2/E411例、E3/E419例。与对照组相比E4的频率明显高于对照组,E3的频率明显低于对照组。结论:E4为慢性硬膜下血肿的危险因素,检测ApoE基因型有助于确认高危人群;E3可能对慢性硬膜下血肿形成有保护作用。 |
| 关 键 词： | 载脂蛋白E 慢性硬膜下血肿 基因表型 |
Evaluation of association of apolipoprotein E genotypes in patients with chronic subdural hematomas |
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| XU Zhen,Gu Zhikai. Evaluation of association of apolipoprotein E genotypes in patients with chronic subdural hematomas[J]. Chinese Medical JOurnal of Communications, 2006, 20(2): 177-178 | |
| Authors: | XU Zhen Gu Zhikai |
| Affiliation: | Department of Neurosurgery, the Affiliated Hospital of Nantong University, Jiangsu 226001 |
| Abstract: | Objective: To explore the relationship between the polymorphisms E(Apo E) gene and chronic subdural hematomas (CSDH).Methods:By using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),the ApoE genotypes of 65 patients with CSDH weve compared with those in normal controls.Results:The alleles frequencies of E4 hemozygotes inpatients with CSDH are elevated significantly,while E3 was significantly lower.Conclusion:The study suggests that E4 homozygotes are risk factors for CSDH and the determination of ApoE genotypes helps to identify patients with particular risks of CSDH. E3 might have the protection for CSDH. |
| Keywords: | Apolipoprotein E Genotype Chronic subdural hematomas |
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