| 消瘤平的急性毒性及抗肿瘤活性的实验研究 |
| |
| 引用本文： | 董晓晖,侯刚健. 消瘤平的急性毒性及抗肿瘤活性的实验研究[J]. 医学理论与实践, 2007, 20(10): 1124-1125 |
| |
| 作者姓名： | 董晓晖 侯刚健 |
| |
| 作者单位： | 菏泽医学专科学校,山东省菏泽市,274030 |
| |
| 摘 要： | 目的:观察消瘤平的毒性及抗肿瘤活性的作用。方法:先以少数(10只)动物做实验,以获得粗略的LD50和LD100,然后在此剂量范围内,取体重18~22g小鼠50只,按等比级数分成5组,每组10只,雌雄各半。结果:以t检验比较消痛平组与对照组的差异,消瘤平组与环磷酰胺(CTX)组的差异无显著性(P>0.05),但环磷酰胺(CTX)组的毒性远大于消瘤平组,消瘤平LD50=3134~4509mg/kg,CTXLD50=580~780mg/kg。结论:消瘤平对肿瘤有明显的抑制作用,是一种发展前景较好的抗癌药。
|
| 关 键 词： | 消瘤平 LD50 抑瘤实验 |
| 文章编号： | 1001-7585（2007）10-1124-02 |
| 收稿时间： | 2007-03-03 |
| 修稿时间： | 2007-03-03 |
Experimental Research on the Toxicity and Anti-tumor Activity of Xiaoliuping |
| |
| DONG Xiaohui,HOU GangJian. Experimental Research on the Toxicity and Anti-tumor Activity of Xiaoliuping[J]. The Journal of Medical Theory and Practice, 2007, 20(10): 1124-1125 |
| |
| Authors: | DONG Xiaohui HOU GangJian |
| |
| Affiliation: | Department of pharmacology Heze Medical college, Shandong Province 274030 |
| |
| Abstract: | Objective: To investigate the toxicity and anti-tumor activity of xiaoliuping.Methods: 10 mice were used in the first experiment to obtain the rough LD50 and LD100,and then 50 mice selected in accordance with body weight of 18~22g were equally divided into 5 groups(half and half in sex in each group).Results: Differences between daministration group and control group and between xiaoliuping group and CTX group were unremarkable(P>0.05),but the toxicity in CTX group exceed that in xiaoliuping group(xiaoliuling LD50=3134~4509mg/kg,CTX LD50=580~780mg/kg).Conclusion:Xiaoliuping shows distinct inhibitory effect on tumour.So it is a king of anticarcinogen with good prospects. |
| |
| Keywords: | Xiaoliuping anti-tumor drug LD50 Carcinostatic experiment |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
