急性脑梗死患者血清白介素-18水平与颈动脉斑块的关系

目的:探讨急性脑梗死患者血清白介素-18(IL-18)水平的变化与颈动脉斑块的关系.方法:将121例急性脑梗死患者(梗死组)根据颈动脉超声结果分为无斑块亚组(37例)、稳定斑块亚组(41例)和不稳定斑块亚组(43例),抽取所有患者发病急性期(1 d)和恢复期(12 d)的空腹静脉血,采用双抗体夹心酶联免疫吸附法(ELI...

Correlation of Carotid Artery Plaques and Serum Interleukin-18 Levels of Patients with Acute Cerebral Infarction

Objective:To explore the relationship of carotid artery plaques and serum interleukin-18 levels in patients with acute cerebral infarction.Methods:Using carotid ultra-sonographic methods,121 patients with acute cerebral infarction were divided into three subgroups,the subgroup no carotid plaques(NCP)(n=37),the subgroup stable plaque(SP)(n=41),and the subgroup vulnerable plaques(VP)(n=43).The Serum IL-18 levels of all patients with acute cerebral infarction and 31 healthy controls were measured by enzyme linked immunosorbent assay(ELISA) at days 1 and 12 after onset.Results:At day 1 and 12 after onset,the IL-18 levels of subgroup VP were significantly increased than other groups(P<0.05).However,the IL-18 levels in the subgroup SP were significantly higher than those in the subgroup NCP and control group(P<0.05).No difference was observed between the subgroup NCP and control group.Conclusion: The level of serum IL-18 in patients with acute cerebral infarction may be a valuable indicator for characteristics of carotid plaques.