Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: a method-dependent error |
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| Authors: | K J Whitlow A A Nanji M R Pudek |
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| Affiliation: | Division of Clinical Chemistry, Vancouver General Hospital and University of British Columbia, Vancouver, B.C. Canada V5Z 1M9 |
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| Abstract: | ![]()
We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-Bio centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used. |
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| Keywords: | blood protein disorders macroglobulinemia multiple myeloma myeloma proteins serum globulins |
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