The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on uridine uptake in the mouse brain |
| |
| Authors: | H. Pakkenberg B. Pakkenberg C. Kjeldsen |
| |
| Affiliation: | 1. Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD 20892, USA;1. Molecular and Functional Neurobiology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 6 Avenue du Swing, 4367 Belvaux, Luxembourg;2. Institute of Neurogenetics University of Lübeck, 23562 Lübeck, Germany;3. Department of Neurogenetics, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, 2065, Australia;4. Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia;5. Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia;1. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA;3. Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA;4. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;5. Parkinson’s Institute and Clinical Center, Sunnyvale, CA 94085, USA;1. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji’nan 250103, Shandong Province, People’s Republic of China;2. Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji’nan 250103, Shandong Province, People’s Republic of China;3. Biological Engineering College, Qilu University of Technology (Shandong Academy of Sciences), Ji’nan 250056, Shandong Province, People’s Republic of China;4. School of Psychology, North China University of Science and Technology, 21 Bohai Road, Tang’shan 063210, Hebei Province, People’s Republic of China;5. Neuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia;1. IFREMER, Dyneco/VIGIES, Rue de l''Ile d''Yeu, BP 21105, 44311 Nantes Cedex 03, France;2. IFREMER, Dyneco/BENTHOS, Technopôle Brest Iroise, BP 70, 29280 Plouzané, France;3. Université de Nantes, Mer Molécules Santé EA 2160, Faculté des Sciences et des Techniques, 2, Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 03, France |
| |
| Abstract: | ![]()
Male white mice were injected with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 40 mg/kg. After 2 h, 24 h, 2, 4 and 8 days 0.25 mCi [5-3H]uridine was injected i.v. and 1 h later the animals were sacrificed. In microautoradiograms the number of grains over the nerve cell nuclei was counted in the substantia nigra, the cerebral cortex, the hippocampus and the neostriatum. In the substantia nigra there was a significant increase in grain number after 2, 4 and 8 days. In a group of animals injected 3 days with MPTP and sacrificed 2 days after the last injection the same increase was found. In the other brain regions only an insignificant increase in grain counts was found. In a special group of animals the total radioactivity and distribution of label on metabolites in blood, brain and liver was determined. No significant changes were found. |
| |
| Keywords: | N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) uridine substantia nigra |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
