系统性红斑狼疮患者并发EB病毒或巨细胞病毒感染的回顾性分析

目的 探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者并发EB病毒(epstein barr virus,EBV)或巨细胞病毒(cytomegalovirus,CMV)感染的流行病学特征,为临床提供参考。方法 回顾性分析2012年1月～2015年4月在南京大学医学院附属鼓楼医院就诊入院的202例女性SLE患者(SLE组)的相关临床资料,以同期的女性肾移植供者和妇产科送检标本共203例作为对照组; 根据实时荧光定量PCR检测外周血中EB病毒DNA和巨细胞病毒DNA结果,分析、比较SLE组和对照组的感染发生率。结果 SLE患者中EBV-DNA的阳性率(11.39%)显著高于对照组的阳性率(3.45%),差异具有统计学意义(χ²=8.28,P<0.01); SLE组CMV-DNA的阳性率(7.92%)显著高于对照组的阳性率(1.97%),差异具有统计学意义(χ²=7.64,P<0.05)。128例育龄期SLE患者EBV-DNA的阳性率(10.94%)显著高于对照组的阳性率(3.45%),差异具有统计学意义(χ²=4.99,P<0.05); 育龄期SLE组CMV-DNA的阳性率(7.75%)显著高于对照组的阳性率(2.22%),差异具有统计学意义(χ²=4.31,P<0.05)。结论 SLE患者易并发EB病毒或巨细胞病毒感染,提示SLE与病毒感染可能具有相关性,在临床工作中应加以重视。

Retrospective Analysis of Epstein Barr Virus or Cytomegalovirus Infection in Patients with Systemic Lupus Erythematosus

Objective To analyze the epidemiological characteristics of Epstein Barr virus(EBV)or cytomegalovirus(CMV)infection in systemic lupus erythematosus(SLE)patients in order to provide reference for clinic.Methods The clinical data of 202 female cases in-patients diagnosed with SLE(SLE group)from January 2012 to May 2015 in Nanjing DrumTower Hospital were analyzed retrospectively.Meanwhile,203 cases including female renal transplant donors,obstetrics and gynecology in-patients selected randomly were enrolled as control group.The infection rate between SLE and control groups was analyzed and compared based on the results of EBV-DNA and CMV-DNAin peripheral blood quantified by real time PCR.Results The positive rate of EBV-DNA in SLE group was 11.39%(23/202),with significantly statistical difference when comparing with the control group [3.45%(6/174)](χ²=8.28,P<0.01).The positive rate of CMV-DNA [7.92%(16/202)]was significantly higher than that in control group [1.97%(4/203)](χ²=7.64,P<0.05).In addition,the positive rate of EBV-DNA and CMV-DNA wasalso greatly higher in reproductive-age(20～45 years old)of SLE patients thanthose in control group,10.94%(14/128)vs 3.45%(4/116)(χ²=4.99,P<0.05)and 7.75%(10/129)vs 2.22%(3/135)(χ²=4.31,P<0.05),respectively.Conclusion SLE patients were more inclined to be accompanying infected by EBV or CMV,indicating the possible correlation between SLEand EBV or CMV infection; and physicians should pay more attention to the viralinfection of SLE in clinical treatment.