男性不育患者体质量指数、腰围与精子质量参数的关系研究

目的 探讨男性不育患者的身体质量指数(body mass index,BMI)、腰围与精子质量参数的相关性。方法 选择门诊和住院男性不育患者303例,测量身高、体重及腰围,并按照BMI执行标准分组,同时检测各组的精子质量各项参数。结果 超重组、肥胖组及重度肥胖组的精子浓度与正常体重组比较,有非常显著性差异(t=3.941,3.782,5.632,P<0.01),超重组、肥胖组及重度肥胖组的精子总数与正常体重组比较,有显著性差异(t=2.117,2.655,8.591,P<0.05或0.01),正常体重组与低体重组之间无差异(t=0.668,P>0.05),精子浓度及精子总数随着BMI增加而逐渐降低; 低体重组、超重组、肥胖组和重度肥胖组的不动精子率均高于正常体重组,有显著性差异(t=2.847,8.592,8.472,5.380,P<0.05); 异常体重各组的精子正常形态率与正常体重组比较均明显降低,差异有统计学显著性意义(t=2.356,5.968,5.156,5.993,P<0.05); 异常体重各组的精子活率与正常体重组比较均明显降低,差异也有统计学意义(t=2.847,8.593,8.472,5.380,P<0.05); 异常体重各组的精子向前运动率与正常体重组比较均明显降低,有显著性差异(t=2.432,11.816,9.588,13.528,P<0.05)。超重组、肥胖组及重度肥胖组精子DNA碎片化指数均高于正常体重组,有显著性差异(t=6.168,7.238,9.309,P<0.05); 低体重组与正常体重组比较,无显著性差异(P>0.05)。结论 身体质量指数异常及腰围增大可引起精子多项参数病理性改变,可能是导致男性不育症发生的重要机制。

Study on Correlation between BMI,WC and Sperm Quality Parameters of Male Infertility

Objective To investigate the correlation between body mass index(BMI),waist circumference(WC)and sperm quality parameters of male infertility.Methods 303 cases of male infertilitypatients including outpatients and inpatients were selected to measure height,weight and WC,and to group according to BMI standards,and sperm quality parameters of each group were detected simultaneously.Results Overweight,obese and severely obese group sperm concentration had very significant difference compared with normal weight group(t=3.941,3.782,5.632,P<0.01); Overweight,obese and severely obese group total sperm count had significant difference compared with normal weight group(t=2.117,2.655,8.591,P<0.05 or 0.01).No difference between the normal weight and low weight group(t=0.668,P>0.05),sperm concentration and total sperm count decreasedwith increasing BMI.Low weight group,overweight,obese and severely obese group were higher than normal sperm immobile body recombination,there were significant differences(t=2.847,8.592,8.472,5.380,P<0.05).Normal sperm morphology rate of abnormal weight and normal weight groups were significantly lower comparison,the difference was significant(t=2.356,5.968,5.156,5.993,P<0.05).Abnormal body weight of each group of sperm motility and normalweight group were significantly lower comparison,and there were significant differences(t=2.847,8.593,8.472,5.380,P<0.05).Forward movement rateabnormal and normal body weight of each group restructuring comparison were significantly lower,and there was a significant difference(t=2.432,11.816,9.588,13.528,P<0.05).Overweight,obese and severely obese group of spermDNA fragmentation index were higher than the normal weight group,which the datashowed a significant differences(t=6.168,7.238,9.309,P<0.05),while there was no statistical significance between low weight group and normal weight group(P>0.05).Conclusion Studies showed that the abnormality of BMI and obesity could cause the changes in sperm parameters which might be an important mechanism of male infertility.